Cumulation

Cumulation (from Latin cumulo “to pile up”) is the accumulation of substances in the human or animal body that can cause various negative consequences, including poisoning and even death. Cumulation can occur when taking several medications at the same time, when using toxic substances, or during prolonged exposure to harmful factors on the body.

Cumulation is due to the fact that the body cannot completely remove all the substances that enter it, and they accumulate in various organs and tissues. This can mean that even small doses of a substance can have a strong effect on the body, causing serious health problems.

In pharmacology and toxicology, accumulation is an important issue, since many drugs and toxic substances can accumulate in the body and cause undesirable effects. To prevent accumulation, it is necessary to follow the rules for taking medications and not use them for a long time without consulting a doctor.

Cumulation is the accumulation of a drug or toxic substance in the body, which leads to an increase in its effect on the body. Cumulation can be caused by several reasons, including slow elimination of the drug from the body, increasing the dose of the drug, or increasing the length of time it is taken.

Cumulation can have serious consequences for human health. For example, if a drug accumulates in the blood in large quantities, it can lead to overdose and even death. In addition, accumulation can cause unwanted side effects such as allergic reactions, headaches, nausea and others.

To avoid accumulation, you must follow your doctor's recommendations on the dosage and duration of taking medications. It is also important to monitor your health and consult a doctor immediately if unwanted symptoms appear.

"Cumulation is the phenomenon of accumulation of a drug in the body. This concept is often used in medicine to describe the process of interaction of various drugs in the patient's body and their overall effect on health. Cumulation can lead to unwanted side effects or even toxic effects on the body if the drugs will be taken in large quantities or on a dosage schedule that does not correspond to the dosage and recommended regimen.

In pharmacology, the concept of cumulation refers to the process when a drug remains in the body for a long time and continues to exert its therapeutic effect or side effects with prolonged use. This occurs because the rate at which the drug is eliminated from the body is much lower than its bioavailability or rate of absorption into the blood. The concept of cumulation is especially relevant in the treatment of a chronic disease, for example, asthma, gastritis, diabetes, etc. In this case, the patient is forced to take medications several times a day or

Cumulation

Definition When different doses of the same substance are administered into the body at the same time, or when two different substances are used, a cumulative effect often occurs. It is expressed in the fact that when summing up individual doses, a total effect is obtained that significantly exceeds the effect of an individual dose. In this case, the concentration of the substance in the blood remains constant, i.e., it is not determined by the individual time of administration of the poison. In other words, a dose of a chloral solution passed through the stomach leads to an increase in the chloral content in the blood for 7-13 hours. As a result, the excess of the administered chloral accumulates in the body, which leads to cumulation.

Similar to the "domino" (or "broken tree") effect, where one broken rod sets in motion an entire system of chains, when the poison is administered in batches or over a short period of time. The behavior of a substance is considered cumulative when “the sum of the sum does not equal the sum.” The result is the accumulation of a substance in which the body is in a state of toxic poisoning. If a substance in most cases acts once, then another poison, after being removed from the body, has a reverse damaging effect on it (resorptive), leading to repeated toxic damage. There are many such substances in pharmaceuticals. For example, atropine in small doses is used in fundus examination, but in overdose it can cause antimuscarinic effects, including respiratory arrest. Likewise, phosphorus compounds have a narrow therapeutic range. In addition, being in high concentrations, they can themselves cause liver necrosis.

Types of cumulative substances There is a concept of relatively harmless poisons that have cumulative properties. Such substances can accumulate slowly and be absolutely safe in low concentrations. For example, barium-containing dyes are safe for humans as long as their amount in the diet does not exceed 4 g/day. This volume allows them to accumulate in organ tissues with simultaneous maximum staining. The leaders in terms of the degree of cumulativeness are, first of all, substances of plant origin; hemp and poppy straw are most often found as drugs. Hemp is a powerful narcotic substance, recognized as the most widespread substance, possessing a large number of types of psychoactive compounds, one of the most dangerous narcotic poisons. Once in the body, cannabinoids penetrate the BBB and accumulate in brain cells and the hippocampus, where they provide a convulsive effect. Heavy physical activity and high ambient temperatures stimulate the activity of the enzyme 5-lipoxygenase and significantly increase the level of TCA acids, which cause severe anaphylactic reactions. Most drugs and their substitutes are toxic or highly toxic compared to local analgesics. Opiates are present in very low concentrations in the gastrointestinal tract and blood, while doses are high enough to produce significant effects. A feeling of euphoria, loss of appetite, diarrhea are replaced by pallor of the skin and mucous membranes, dizziness, slow breathing, nausea and vomiting, increased by