Lange Curve

The Lange Curve is a method for determining excess protein globulins present in the cerebrospinal fluid. This method was developed at the beginning of the 20th century by the German bacteriologist Friedrich Lange and was first used to diagnose neurosyphilis and multiple sclerosis.

The Lange curve is based on determining the amount of protein in the cerebrospinal fluid by electrophoresis. In this case, an electric current is passed through the cerebrospinal fluid, and proteins begin to separate into components depending on their charge and mass. The resulting data is then used to construct a graph known as the Lange curve.

The Lange curve can be used to determine the presence or absence of excess globulins in the cerebrospinal fluid. In the case of neurosyphilis and multiple sclerosis, excess globulins may indicate the presence of these diseases.

However, the Lange curve has now fallen out of use as a diagnostic test for these diseases. This is because there are more advanced diagnostic tests, such as antibody tests and molecular techniques, that can more accurately identify the presence of these diseases.

However, the Lange curve remains a significant scientific advance that has helped improve the diagnosis of certain diseases in the past. It is worth noting that modern methods for determining the excess content of globulins in the cerebrospinal fluid are largely based on the principles laid down in the Lange curve method.

The Lange Curve is a method for determining the excess content of globulins in a protein, which was previously widely used in medicine for the diagnosis of neurosyphilis and multiple sclerosis. This method was based on measuring the amount of protein in the cerebrospinal fluid and plotting its concentration versus time.

The Lange curve was developed in the 1930s by German neurologist and psychiatrist Alfred Lange. He proposed using this method to diagnose neurosyphilis, since with this disease there is an increased content of globulins in the cerebrospinal fluid. In subsequent years, the method was successfully used to diagnose multiple sclerosis, which is also accompanied by an increase in the amount of globulins in the cerebrospinal fluid.

However, despite its effectiveness, the Lange Curve method had a number of disadvantages. It was quite labor-intensive and required a large amount of cerebrospinal fluid for analysis. In addition, this method did not make it possible to accurately determine the type of globulins, which could lead to false results.

Today, the Lange Curve method has fallen into disuse and has been replaced by more advanced diagnostic tests such as immunoblotting and immunoelectrophoresis. They allow you to accurately determine the type of globulins and conduct a more detailed analysis of the cerebrospinal fluid.

Thus, the Lange Curve is an interesting historical method that played an important role in the diagnosis of neurological diseases in the past. However, it has now given way to more modern and accurate methods of analyzing cerebrospinal fluid.

There are many diagnostic research methods in the diagnosis of various diseases. One of these is the determination of the concentration of globulin in the spinal fluid. The higher the globulin content, the more complex the course of the disease and recovery is more difficult. Not so long ago, the Lange curve was used to determine the presence of globulin components, but now diagnostics are carried out using high-quality microbiological reagents and biological spectrometers. However, the history of the development of this method is still relevant among the scientific community and doctors.

The Lange curve was developed in 1934 by the famous German doctor Rudolf Lange. After a series of studies, he found out that the presence