What is a "lepromatous reaction"? It is a disease that can have a variety of causes, but is usually associated with bacterial infections such as leprosy or syphilis. If you experience this condition, it is important to see a medical professional as soon as possible as it can lead to serious complications such as hearing or vision loss. Lepromatous lesion is an internal lesion of the skin and internal organs caused by a bacterial infection of leprosy or inguinal bubo. Symptoms of the disease include skin rash, abdominal pain and swollen lymph nodes. Treatment of lepromatic disease consists of taking antibiotics and other medications