Liver Fibrosis

Liver fibrosis: understanding, causes and treatment

Liver fibrosis (hepatitis fibrosis) is a pathological condition characterized by the formation of excess collagen fibrous matrix in liver tissue. This is a response to liver damage and may be a precursor to cirrhosis, a serious and irreversible disease.

The process of liver fibrosis begins with damage to hepatocytes, the main functional cells of the liver that perform a number of important functions, including food processing, detoxification, and protein synthesis. The damage can be caused by a variety of causes, such as chronic viral hepatitis B or C, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune diseases, genetic disorders, or long-term use of certain medications.

When hepatocytes are damaged, stellate cells, the main producers of collagen in the liver, are activated. These cells begin to produce excess amounts of collagen, which leads to scar formation and fibrosis. As fibrosis progresses, normal liver tissue is replaced by fibrotic scar, limiting normal liver function.

Diagnosis of liver fibrosis may involve various methods such as liver biopsy, liver elastography (a non-invasive method for measuring liver stiffness), blood tests to assess liver function and detect markers of fibrosis.

Treatment for liver fibrosis aims to stop or slow the progression of the disease. The main goal is to treat the underlying disease that is causing liver damage. For example, for viral hepatitis, antiviral therapy may be prescribed, and for alcoholic liver disease, a complete cessation of alcohol consumption. In some cases, liver transplantation may be recommended, especially in cirrhosis, where liver function is severely impaired.

More recent research suggests that certain medications, such as fibrogenesis inhibitors or antioxidants, may help slow the progression of liver fibrosis and improve the patient's condition.

In conclusion, liver fibrosis is a serious disease that can progress to liver cirrhosis if not detected and treated on time. Early diagnosis and treatment of the underlying disease are key measures to prevent the progression of liver fibrosis and preserve the normal function of this important organ. Regular consultation with your doctor, following recommendations for a healthy lifestyle and treatment of the underlying disease can help patients with liver fibrosis achieve better results and improve their overall condition.