Lopressor

Country of origin - Switzerland
Pharm-Group - Beta1-blockers (cardioselective)

Manufacturers - Ciba-Geigy (Switzerland)
International name - Metoprolol
Synonyms - Betaloc, Betaloc ZOK, Vasocardin, Vasocardin retard, Corvitol, Corvitol 100, Corvitol 50, Methohexal, Metocard, Metocard retard, Metolol, Metoprolol, Metoprolol OF, Metoprolol OF 200 retard, Metoprolol-Acri, Metoprolol-Ratiopharm, Metoprolol- Teva , Serdol

Dosage forms - film-coated tablets 50 mg, film-coated tablets 100 mg, injection solution 5 mg, retard film-coated tablets 200 mg

Composition - Active substance - Metoprolol.

Indications for use - Arterial hypertension of moderate to moderate severity (monotherapy or in combination with other antihypertensive drugs), coronary heart disease, hyperkinetic cardiac syndrome, heart rhythm disturbances (sinus tachycardia, ventricular and supraventricular arrhythmia, including paroxysmal tachycardia, supraventricular tachycardia, extrasystole, flutter and atrial fibrillation, atrial tachycardia), hypertrophic cardiomyopathy, mitral valve prolapse, myocardial infarction (prevention and treatment), migraine (prevention), thyrotoxicosis (complex therapy); treatment of akathisia caused by neuroleptics.

Contraindications - Hypersensitivity, AV block II and III degree, sinoatrial block, acute or chronic (in the stage of decompensation) heart failure, sick sinus syndrome, severe sinus bradycardia (heart rate less than 60 beats/min), cardiogenic shock, arterial hypotension (systolic Blood pressure less than 100 mm Hg), severe peripheral circulatory disorders, pregnancy, breastfeeding. Restricted for use in: diabetes mellitus, hypoglycemia, severe allergic history, metabolic acidosis, bronchial asthma, emphysema, non-allergic bronchitis, hyperthyroidism, psoriasis, pheochromocytoma, impaired liver and/or kidney function, myasthenia gravis, depression, general anesthesia, elderly and children age.

Side effects - From the nervous system and sensory organs: weakness, dizziness and headache, decreased concentration, drowsiness/insomnia, nightmares, depression, muscle cramps, paresthesia, nervousness, anxiety, decreased libido, blurred vision, xerophthalmia, conjunctivitis, lethargy, fatigue, anxiety, confusion, amnesia/short-term memory loss, hallucinations, tinnitus, impaired taste. From the cardiovascular system and blood (hematopoiesis, hemostasis): bradycardia, palpitations, hypotension, cold extremities, heart failure, AV block, edema syndrome, chest pain, decreased myocardial contractility, arrhythmias, gangrene, impaired myocardial conduction, syncope, thrombocytopenia, leukopenia, agranulocytosis. From the gastrointestinal tract: nausea, abdominal pain, diarrhea or constipation, vomiting, dry mouth, liver dysfunction; flatulence, dyspepsia, heartburn, hepatitis. From the respiratory system: shortness of breath, bronchospasm, vasomotor rhinitis, dyspnea. From the skin: rash, degenerative skin changes, reversible alopecia, photosensitivity, exacerbation of psoriasis; itching, erythema, urticaria, hyperhidrosis. Other: weight loss, arthralgia, arthritis, myalgia, muscle weakness, Peyronie's disease.

Interaction - Hypotension is potentiated by sympatholytics, nifedipine, nitroglycerin, diuretics, apressin and other antihypertensive drugs. Antiarrhythmic and anesthetic drugs increase the risk of bradycardia, arrhythmia, and hypotension. Digitalis preparations potentiate