Macrocytosis

Macrocytes (also erythrocyte hypertrophy, tanycytosis - from the Greek macros - large, cytos - cell; “super-large erythrocytes”) - erythrocyte indices, reflecting changes in the total volume of erythrocytes and (or) its individual components (for a complete erythrocyte, the volume is measured as MCV or average volume erythrocyte, MCH: total hemoglobin in one era. The determination of macrocytosis is often used by doctors of various specialties for the primary diagnosis of many diseases of connective tissue, liver, endocrine glands and so on..

Causes of macrocytosis: - hemoconcentration. Insufficient fluid intake or kidney disease may play a role; - mechanical fragmentation of erythrocytes; - iron deficiency in food or iron deficiency anemia. This may be due to chronic blood loss or impaired absorption of iron in the intestine;

Deficiency of vitamins and minerals: Deficiency of folic acid, vitamin B12 or vitamin C can lead to microcytosis, macrocytosis and anisocytosis. Metabolic diseases: hemochromatosis, hereditary spherocytosis and its causes. In these conditions, the amount of iron entering the bloodstream increases, causing not only megaloblastic anemia and macrocystic