Malate dehydrogenase

Malate dehydrogenase is an enzyme from the group of oxidoreductases that catalyzes the oxidation of L-malate to oxaloacetate. The oxidation reaction of malate to oxaloacetate is part of the Krebs cycle and is important for energy production in the cell.

Malate dehydrogenase is present in the cytosol of cells of almost all living organisms. This enzyme contains the cofactor NAD+, which is reduced to NADH during the reaction. Malate dehydrogenase plays a key role in carbohydrate metabolism and providing energy to the cell.

Disturbances in the functioning of malate dehydrogenase can lead to various pathologies associated with the accumulation of excess amounts of malate in cells and tissues. Measurement of the activity of this enzyme is used in the clinical diagnosis of a number of diseases. Thus, malate dehydrogenase plays an important role in the normal functioning of cellular metabolism.

Malate dehydrase is an enzyme that plays an important role in energy production in humans and animals through the oxidation of glucose. It catalyzes the conversion of malate to oxaloacetate, which is the first step in the TCA cycle (Krebs cycle). This enzyme is also involved in many other metabolic processes such as glycogenolysis, glycolysis, fatty acid oxidation, etc. In this article, we will look at the role of malate dehydrase in energy production, as well as its biological aspects and function.

Role of malate dehydrase in energy production

Malate dehydrogenase is a key enzyme in the TCA cycle (Krebs cycle), which is responsible for the processing of glucose and the production of ATP. This cycle occurs in all cells of the body, where ATP is used to produce energy and regulate various cellular processes. Malate dehybrase plays a central role in starting the TBA cycle by converting malate into a second product, oxalate. The oxaloacetate cycle is a powerful source of energy production because it produces CO2 and NADH molecules, which are then converted into other products. These intermediates provide energy for many important physiological processes.

Malate dehybrin synthesis occurs in the liver, kidneys and nervous system. Most red blood cells also synthesize this enzyme, but in small quantities. Malate dihydronse levels can fluctuate significantly depending on the level of anaerobic glycogen in the blood and liver. Its levels are typically high in the liver and low in platelets.

Malate dehydrogenase levels are elevated in some conditions, including tumors, aspirin overdose, and infections. Not enough information