Microencapsulation in Pharmacy

Microencapsulation in pharmacy

Microencapsulation is a technology widely used in the pharmaceutical industry. It consists of enclosing a very small amount of a drug substance in a shell in order to separate the components of complex drugs that react with each other.

The microencapsulation process allows:

1. Improve the bioavailability of drugs. Microcapsules protect the active ingredient from the destructive effects of stomach acid, enzymes and other factors. This increases its bioavailability when taken orally.

2. Prolong the effect of the drug. The gradual release of the active substance from the microcapsule shell provides a long-lasting therapeutic effect.

3. Mask the unpleasant organoleptic properties of certain medicinal substances, such as taste and smell.

4. Separate incompatible ingredients of complex dosage forms. For example, microencapsulation of one of the components of a prolonged dosage form helps prevent premature interaction and inactivation of active substances.

Thus, microencapsulation technology makes it possible to improve the pharmacokinetics and pharmacodynamics of drugs, increase their effectiveness and safety. This is a very promising area of ​​modern pharmaceuticals.

Microencapsulation in pharmacology is the separation of components of a complex drug that react with each other into their component parts in such a way that each of them is enclosed in a separate (its own) protective shell.

What does a microcapsule do? When they talk about the safety of drugs, they mean two aspects related to pharmacokinetics and pharmacodynamics. The acceptable minimum amount of a drug that has a therapeutic effect is determined by the concentration of the drug in the biological fluids of the body. As the dose increases, there is a risk of overdose and adverse events. They are caused by an increase in drug concentration or an increase in the number of binding sites. That is, pharmacology -