Moduretic

Moduretic is a combination drug containing two active substances: amiloride and hydrochlorothiazide.

Amiloride belongs to the group of potassium-sparing diuretics. It blocks the action of aldosterone in the renal tubules, causing excess sodium and water to be excreted while retaining potassium.

Hydrochlorothiazide is a thiazide diuretic that enhances the excretion of sodium, chlorine and water ions through the kidneys.

The combination of these drugs in Moduretic provides a pronounced diuretic and hypotensive effect. Moduretic is prescribed for the treatment of edema caused by congestive heart failure, cirrhosis of the liver, or renal failure. It is also used for arterial hypertension, when monotherapy with thiazide diuretics is ineffective.

Good afternoon, fellow pharmacologists and simply interested people. Today I would like to tell you about a drug called Moduretic. This medicine belongs to a group of drugs called angiotensin II receptor inhibitors. They are used to treat high blood pressure (hypertension).

Moduretic is created from amiloride, a substance that was first isolated from the root of a species of yucca plant. Yucca was known to Indian tribes and was used to treat various diseases such as cystitis, nephritis and other urinary tract infections. However, the true therapeutic effect of this plant became known only in the 20th century, when more detailed research was carried out.

Amiloride has unique properties that help lower blood pressure. It acts on receptors in the body that regulate blood vessels. These receptors respond to angiotensin, a substance that regulates blood pressure and is an important component of our circulatory system.