Necrosis Radiation Early

Radiation necrosis is a group of pathological changes in tissues or organs caused by the negative effects of ionizing radiation; as a rule, it is observed in areas of irradiation indirectly (through air or other materials). Clinical forms of radiation necrosis are determined by the period of its development and stage of development. There are four clinical and morphological types of necrosis: early, atopic, hypostasis and late.

Early necrosis, characterized by inflammatory reactions of the irradiated tissue followed by its atrophy and scarring. In a similar way, a destructive process develops in irradiated skin, bone, and cartilage of the respiratory system. The mechanism of development of early N. is that, under the influence of rays, healthy tissue having a thickness of less than 0.5 mm is damaged. As a result, the number of free radicals and lysosomal enzymes increases, which activate the inflammatory response of tissues and serve as a trigger for the early necrotic process. In the early stages of cell damage, vascular disorders and expansion of capillaries occur with a sharp deterioration in blood circulation, the appearance of red blood cells and hemoglobin in the intercellular gaps, and the effusion of blood cells into the interstitium. Simultaneously destructive