Pain relief is a set of measures aimed at reducing pain with the help of medications or methods used both before, during, and after surgical treatment. Pain perception and transmission of information about pain to the central nervous system are the result of the interaction of specific receptors that are sensitive to various types of mediators, tissues, organs, body systems and the nervous system as a whole. Painful sensations can occur during diagnostic procedures, manipulations, surgical interventions, etc. To relieve pain of various types and degrees of intensity, various painkillers are used in medicine. These include analgesics (non-steroidal anti-inflammatory drugs or antispasmodics), superficial and general anesthetics, neuroleptics and others.