Tumor Barr-Positive

Tumor Barr-positive

A Barr-positive tumor is a tumor whose cells contain sex chromatin (Barr bodies).

Sex chromatin is a compacted region of one of the X chromosomes in female cells. This compacted area was first described by Edinburgh pathologist Murray Barr in 1949, hence the name Barr's body.

The presence of Barr bodies in tumor cells indicates that the tumor is of female origin. That is, it arose from cells that carry two X chromosomes.

Barr-positive tumors are most often represented by malignant tumors of the female genital organs (breast cancer, ovarian cancer), as well as lymphomas and sarcomas.

Thus, detection of Barr bodies in tumor cells makes it possible to establish its female origin and provides important diagnostic information for choosing treatment tactics.

The tumor term “Burnett-positive tumor” covers a wide range of neoplasms characterized by the presence of certain structures or inclusions associated with cell division and cell nutrition. These may be plasma cells without secreting immunoglobulin, cells of the mammary glands, lungs and respiratory tract, or small cell carcinoma. These features can manifest themselves in the form of various morphological differences and microscopic examination of the biopsy material.

Barr-positive test is a test to detect sex chromatin in cells, which indicates the presence of special sex chromosomes called the Y chromosome. Bar