Osteodystrophy

Osteodystrophy is a generalized bone disease associated with metabolic disorders in the body.

Renal osteodystrophy is one of the forms of this disease. It is characterized by certain changes in the bones that are usually observed in chronic renal failure.

With renal osteodystrophy, disturbances in phosphorus-calcium metabolism are observed, caused by a decrease in the excretory function of the kidneys. This leads to the accumulation of phosphates in the blood, hyperphosphatemia. In response to hyperphosphatemia, the production of calcitriol, the active form of vitamin D, which is involved in the regulation of calcium and phosphorus, is reduced.

As a result, hypocalcemia develops and bone mineralization is impaired. Osteoporosis, osteosclerosis, osteomalacia and other degenerative bone changes are formed in renal osteodystrophy. Thus, osteodystrophy in chronic renal failure is a consequence of complex disorders of mineral and bone metabolism.

Osteodystrophy is a generalized disorder of metabolic processes in bone tissue and connective tissues of the body. It manifests itself as atrophy of the superficial and spongy layers, disruption of the integrity of bone tissue, and a decrease in the growth of osteocytes.

Osteodystorophic processes

Osteodystrophy is a hypocalcemic or hypercalcemic general bone disease with progressive dystrophic damage to all bone organs (skeleton, trachea) and with a decrease or disruption of the formation of bone substance. It is classified as a metabolic bone disease. Currently, the predominant international classification