Pdrn drug against wrinkles and skin aging

Polynucleotides (PDRN) have become a real sensation in the world of cosmetology. Polynucleotides are precisely those “building blocks” that restore the structure of the skin from the inside, increasing collagen production.

Currently, completely new and unique technologies have emerged that are designed to combat the causes of aging!

PDRN is a “prodrug” that supplies cells with a sufficient amount of mitogenic deoxyribonucleotides, deoxyribonucleosides and nitrogenous bases.

Advantages of the drug

Effect of PDRN on the skin:

• stimulate repair processes
• accelerate reepithelation and skin scarring
• ensure rapid and harmonious formation of granulation tissue in the wound area
• increase the metabolic activity of cells
• stimulate angiogenesis (restore microcirculation in tissues)
• enhance the moisturizing effect of hyaluronic acid
• reduce the level of the pro-inflammatory cytokine TNF-a (reduction of inflammatory manifestations of acne)
• are highly effective traps of free radicals (protect against damage by metabolites, xenobiotics, temperature factors, etc.)
• protect against UVB radiation and prevent the development of pigmentation

Safety of PDRN

By its structure, PDRN is a fragment of a DNA molecule, a unique polymer molecule with multifaceted positive properties that affect cellular processes in the human body and homeostasis with the absence of toxicity and contraindications. Research by scientists has shown that low molecular weight DNA with a molecular weight of no higher than 500 kDa does not carry genetic information. It is known that such low molecular weight DNA cannot cause genetic transformation even in bacterial systems. There are no allergic or other negative reactions or serious unwanted side effects.

Efficiency of PDRN

At the stage of preclinical research, the possibility of using the DNA-RNA complex in aesthetic medicine and its activity “in vitro” in a test system, which was a culture of human epidermal cells, was studied. The complex significantly affects cell metabolism, increasing the rate of synthesis of intracellular proteins and DNA by 1.5-2.5 times, while the pronounced effect depends on the concentration of the complex. It has been proven that the identified stimulation effect spreads through the immunocompetent cells of the epidermis to the entire immune system of the body as a whole, that is, the state of the immune system of the entire body is normalized.

TwAc. New generation drugs based on polynucleotides

Indications:

• recovery after traumatic procedures (laser resurfacing);
• moisturizing the skin of the neck, face, back of the hand and décolleté area
• elimination of wrinkles;
• increasing skin hydration and elasticity;
• giving the skin radiance.

Injection level: intradermal, possibility of bruising is low.

Packaging: volume 3 ml. This is enough for the face, neck, décolleté and hands.

The innovative formula of TwAc is based on hyaluronic acid and polynucleotides. Polynucleotides, or PDRN for short, are tiny DNA fragments of the highest purity. Polynucleotides are a “prodrug” that supplies cells with a sufficient amount of mitogenic deoxyribonucleotides, deoxyribonucleosides and nitrogenous bases.

The combined action of these components leads to a number of effects:

• stimulate the processes of repair and renewal;
• accelerate skin reepithelialization;
• ensure rapid and harmonious formation of granulation tissue in the wound area (fast wound healing);
• increase the metabolic activity of cells;
• stimulate angiogenesis (improving blood supply to tissues);
• enhance the moisturizing effect of the hyaluronic acid included in the preparation;
• reduce the level of pro-inflammatory cytokine TNF-a;
• are highly effective traps of free radicals that “devour” healthy cells.

Mechanism of action of TwAc

Due to the high concentration of PDRN and the high viscosity of hyaluronic acid, we obtain a long-lasting and powerful modulating effect on skin cells. Long polymer chains of polynucleotides provide the ability to bind water molecules, thereby enhancing overall hydration. There is also an increase in the growth and division of skin cells (including fibroblasts), which has a powerful self-rejuvenation effect. As a result, active tissue regeneration occurs. With the complex effect of the active components of the TwAc line of drugs, the production of growth factors increases, collagen synthesis is stimulated, and DNA repair is activated. All layers of the skin are renewed and damaged tissues are restored, age-related changes are prevented and treated, complexion improves, turgor and elasticity increase, skin tone is restored, wrinkles of small and medium depth are corrected.

Before the biorevitalization procedure, anesthesia is performed by applying a cream. Biorevitalization is carried out in individual courses.

Recovery period and side effects

After injection, slight swelling and redness of the skin may be observed. These side effects are local in nature and disappear on their own after a few hours.

Result. Biorevitalization with hyaluronic acid increases elasticity, density, skin turgor, saturates it with life-giving moisture, improves structure and color. After a course of procedures, the relief is evened out, small wrinkles are smoothed out, deep wrinkles become less distinct, and the oval of the face is tightened.

Price for injection procedure based on PDRN (PDRN)

Price

1% complex based on PDRN (PDRN)

3% complex based on PDRN (PDRN)

PDRN - indeed, a real sensation. They are the very “building blocks” that restore the structure of the skin from the inside, damaged by external factors, as well as age-related and hormonal changes, stimulating protein production.

These are fundamentally new, unique technologies based on PDRN, which can fight not the signs, but the very cause of aging. In medicine and cosmetology, PDRN is recognized as a “prodrug” that supplies cells with mitogenic deoxyribonucleotides, nitrogenous bases and deoxyribonucleosides in sufficient quantities.

Efficiency of polynucleotides
The possibility of using drugs in a DNA-RNA complex was studied in the framework of in vitro test systems for aesthetic medicine at the stage of preclinical studies. The test system chosen for study was a culture of human epidermal cells. The results were obtained:

1. the rate of DNA and intracellular protein synthesis increased by one and a half to two times;
2. the severity of the effect was directly dependent on the concentration of the complex.

Thus, the mechanism of influence of PDRN on cellular metabolism was proven. A pronounced stimulating effect was manifested due to the action of immunocompetent cells of the epidermis on the general immunity of the body. Thus, it was concluded that not only local, but also general stimulation and strengthening of the human immune system due to the action of polynucleotides.

Drugs containing PDRN and their effects
In cosmetology, products based on polynucleotides are recommended for use. with photoshop effect:

1. H1 SUPER S. DNA.

The complex contains active PDRN - salmon DNA, the effect of which is enhanced by additional active components of the drug:

1. one percent hyaluronic acid;
2. one percent DNA;
3. one percent glutathione;
4. pentapeptide and acetylhexapeptide-8 at a concentration of 0.05% each, respectively;
5. adenosine at a concentration of 0.04%;
6. retinol at a concentration of 0.01%.

Available in 5 ml bottles.
The effect is pronounced, provides deep skin regeneration and a visible anti-inflammatory effect.

Positive changes are noticeable after the first use. First of all, this is visible skin rejuvenation.

Mechanism of action of the complex
Characterized by a combination of restorative factors:

1. direct restoration of damaged DNA structures begins due to bioreparation of cell fibroblasts;
2. the action and structure of capillaries is restored;
3. an extracellular matrix, a skin framework, is formed due to an increase in the formation of collagen and non-collagen protein in skin cells;
4. has a powerful anti-inflammatory effect;
5. antiradical and antioxidant factors and mechanisms are activated;
6. the skin is moisturized;
7. thanks to the normalization of melanogenesis, improvement in skin color, whitening, and leveling of pigmentation are recorded;
8. skin immunity increases. >

2. HP GELL REGATION Skinbooster Serum 3

A characteristic advantage of this complex is the absence of side effects during and after its use. The drug includes the following active ingredients:

1. PDRN directly at a concentration of 0.7%;
2. auxiliary substances that enhance the effect of polynucleotides: Tranexamic Ac />
3. The mechanism and principle of action is as follows:
4. direct restoration of damaged fibroblasts in the cell DNA structure begins. Thanks to this, the processes of bioreparation of skin cells are activated;
5. the amount of non-collagen/collagen protein increases, its formation accelerates, thereby creating a clear framework, extracellular matrix;
6. there is a visible anti-inflammatory effect of the drug;
7. pronounced antiradical and antioxidant activity is recorded;
8. there is a high level of hydration;
9. effective whitening and removal of pigmentation are registered due to the normalization of melanogenesis processes;
10. optimization and strengthening of the skin’s immune defense and its local immunity are determined.

Together, all this gives a powerful, pronounced and noticeable anti-age effect.
The advantage and argument in favor of using polynucleotide complexes is that PDRN is a substance that is safe for the human body and does not harm it. It is present in human cells, is related to them, and is an important activator of synthesis and regeneration of tissues and cells in the body. In particular, it stimulates metabolic processes and fibroblast regeneration. >

Based on this, it can be stated that:
1. PDRN have received well-deserved recognition as a new generation of drugs for anti-age injection procedures.
2. PDRN has become a new era in age-related cosmetology, the basis for fundamentally new, more advanced procedures for rejuvenating the face and body.
3. PDRN is distinguished by proven effectiveness and safety, which is confirmed by the accumulated experience in preclinical development and clinical trials of drugs based on them.

Why is PDRN increasingly becoming a favorite among estheticians and patients?
The main “secret” is the peculiarities and effectiveness of the composition of the complexes, in the combination of purine (guanine and adenine) and pyrimidine (thymine and cytosine) bases in the composition of the polydeoxyribonucleotide.

As a result, PDRN activates the physiological repair of fibroblasts, which helps restore their functional activity.

Increasing the PDRN concentration to two percent increases the intensity:
— synthesis of collagen structures, which leads to increased turgor and skin tone;
- synthesis of fibrillar fibers, glycosaminoglycans, elastins, which leads to increased firmness and elasticity of tissues;
- synthesis of essential hyaluronic acid, which provides natural skin hydration.
In addition, PDRN has been proven to have a powerful anti-inflammatory effect.

Additionally identified:
— activation of the angiogenesis process, providing therapy for rosacea, relief of pastosity and optimization of microcirculation;
— general normalization of melanin production, a pronounced skin whitening effect;
- significant antioxidant effect.

An aesthetic breakthrough in the world of cosmetology – new generation drugs based on polynucleotides (PDRN). Polynucleotides are precisely the building material that restores the skin from the inside, increasing collagen production at the genetic level.
In injection cosmetology, preparations with PDRN are used to activate the process of skin cell regeneration and their natural revitalization. This is due to the high antioxidant activity of polynucleotides, called “molécules de vie” in France.

Unique filler with PDRN complex, Renaissanсe System 2

Indications for use of polynucleotides (PDRN)

In injection cosmetology, polynucleotides are used in the following cases:

1. with fine-wrinkled type of aging;
2. with sagging and sagging skin;
3. with thinning skin of the face, neck, décolleté, hands;
4. for bioreinforcement to produce your own collagen;
5. for natural skin tightening;
6. for rejuvenation of the periorbital zone.

Contour plastic surgery with Renaissance PDRN filler for RUR 10,800 9,720!

Special price for line drugs for 1 ml.!

Hurry! There is only one day left until the end of the promotion!
Valid until 07/18/2019

Purposes of using polynucleotides in injection cosmetology

1. correction of the nasolacrimal groove without swelling and bruising,
2. reduction of intrinsic pastiness of the infraorbital region;
3. bioreinforcement of the skin around the eyes in the presence of fine wrinkles,
   "crow's feet"
4. restoration of elasticity of flabby thin skin of the periorbital area.

Biorevitalizant, a bioreparant with a PDRN complex - Renaissance System 1, is an effective analogue of one of the most popular boosters in cosmetology TwAc (Fig. 4)

I am glad to welcome you to my website!

Hello! My name is Olga Vanskaya. I am a professional cosmetologist with a medical education and 9 years of experience in the field of injection cosmetology. Reviews of my work can be read here, as well as in the group In contact with And Facebook.. If you have any questions about procedures, drugs or prices presented on the site - I will advise you for free by phone or via Whats app +7 (921) 418-56-18

Indications for the use of biorevitalizants with a polynucleotide complex

1. age-related changes in the skin around the eyes;
2. pastosity and swelling of the periorbital area;
3. “tired eyes” syndrome, dark circles under the eyes.

One of the most popular boosters in cosmetology TwAc

Reviews after using polynucleotides (PDRN)

“The effect is obvious, safe and slow to appear. Quite a new word for a client who is accustomed to the usual and, even with frequent use, boring biorevitalizations and mesotherapy...
It doesn’t hurt to prick, but it’s still not a mesotherapy cocktail with vitamins or peptides, which sometimes cause pain...
It completely relieves inflammation on skin prone to it, and tightens and rejuvenates it.
And the result is consolidated by a repeated procedure, which, which is extremely convenient, can be done after 3-4 weeks, and not after the usual couple of weeks for cosmetology martyrs.
Well, it’s beautiful for a long time afterwards”

“...At first I was skeptical... I bought a package of the drug with a polynucleotide concentration of 2.5% and tried it on myself. My verdict: the effect is not immediate... but for the sake of such an effect you can be patient))... The skin “glows” with freshness, an excellent hydration effect and an obvious lifting effect.”