Procyclidine (Procyclidine)

Procyclidine is a medicinal substance similar in its action to atropine; used to reduce tremor and muscle rigidity in parkinsonism. Can be administered orally or by injection; possible side effects: dry mouth, blurred vision and dizziness. Trade names: arpicolin (Arpicolin), xmadrin (Kemadrin).



Procyclidine is a drug that is used to treat parkinsonism, tremors, and muscle stiffness. It acts like atropine, decreasing muscle activity and reducing tremors.

Procyclidine is available in two forms: tablets and injections. Tablets are taken orally, and injections can be given intramuscularly or intravenously.

Side effects associated with procyclidine include dry mouth, blurred vision, and dizziness. These side effects are usually mild and temporary and should go away once you stop taking the drug.

Trade names for procyclidine include arpicoline and xmadrin. They are available in pharmacies and can be purchased without a prescription. However, before starting any medication, you should consult your doctor.



Procyclidine is a drug that belongs to the class of peripherally acting opioid agonists. It was developed to treat diseases and symptoms associated with movement disorders. This compound is used primarily for the treatment and prevention of parkinsonism, as it can reduce tremors and muscle rigidity in patients with this diagnosis.

The mechanism of action of procyclidine is based on its ability to block histamine M1, M2 and M3 receptors and M receptors, which are involved in the regulation of muscle tone. Thus, procyclidine blocks the transmission of impulses between these receptors and reduces muscle tone, which leads to improved motor function and reduced tremor.

It is important to note that procyclidine has a number of side effects that can be significant in some patients. Some of these side effects include dry mouth and vision problems such as diplopia (double vision) and papilledema. There are also known cases of dizziness, loss of coordination and headaches after using this drug. Some patients may also experience trouble sleeping, decreased concentration, and difficulty learning new skills due to the sedative effects of this drug.

When using procyclidine orally, gastrointestinal disorders may occur, including nausea, vomiting, and stomach cramps.



I. Introduction

Procyclidine is the drug of choice for the treatment of tremor in parkinsonosis. It is a prodrug because it undergoes biotransformation in the body into an active metabolite, similar to the effects of atropine, which reduces muscle rigidity and tremors in this disease. In this article we will look at the features of pharmacology