Prothrombokinase

Introduction

Prothrombokinase is a plasma enzyme that is responsible for the formation of a clot from fibrin under the influence of thrombin. Prothrombin becomes the active form by combining with the Xa-dependent serine proteinase, coagulation factor 8. Then the active forms of these proteins are joined by a number of others involved in tissue activation. Fibronectin, factor XIII and vitronectin are involved in the formation of the membrane, and thecaporins and trypsin cause its strength.

Application

Typically, prothrombinase is involved in platelet disaggregation and the treatment of thrombosis and thromboembolism. Preparations based on prothrombinase significantly improved treatment results and reduced the risk of complications in comparison with thrombolytic drugs. However, there are certain concerns regarding their safety that prevent their use for restoring normal circulatory structure. For example, hemorheological studies indicate an increased risk of thrombophlebitis. Among the unfavorable outcomes are