Radionecrosis, Radiation Necrosis (Radionecrosis)

Radionecrosis, Radiation Necrosis (Radionecrosis): causes, symptoms and treatment

Radionecrosis, also known as Radiation Necrosis, is a serious complication of radiation therapy that can lead to tissue necrosis. This mainly concerns bone tissue or skin, which receive the greatest amount of radiation during the course of antitumor therapy. In this article we will look at the causes, symptoms and treatment methods of radionecrosis.

Causes of radionecrosis

Radionecrosis occurs due to inhibition of the tissue's ability to regenerate after receiving radiation. This means that the tissue cannot replace damaged cells and can eventually lead to necrosis. In addition, trauma or surgery after radiation therapy can enhance the process of radionecrosis. Weakened tissue becomes more vulnerable to injury, which in turn can lead to the development of necrosis.

Symptoms of radionecrosis

Symptoms of radionecrosis depend on what tissue was damaged and how severe it was. In the case of bone tissue, symptoms may include tenderness, swelling, skin discoloration, pustular discharge, or even bone destruction. The skin may become thinner, less elastic, and more prone to ulcers.

Treatment of radionecrosis

Treatment for radionecrosis depends on the extent of tissue damage. In mild cases, topical treatment may be required to reduce pain and prevent infection. In more severe cases, surgery may be required to remove the damaged tissue. In some cases, amputation of the affected limb may be necessary.

In some cases, treatment with oxygen therapy, which increases the amount of oxygen reaching the damaged tissue and stimulates its regeneration, may be effective. This treatment can be used in combination with other methods such as hyperbaric oxygen therapy, which also increases the amount of oxygen in the tissue.

In conclusion, radionecrosis, Radiation Necrosis, is a serious complication after radiation therapy that can lead to tissue necrosis. It is important to know the symptoms and treatments so that you can seek medical help promptly and reduce the risk of complications.

Radionecrosis is the necrosis of tissue, in particular bone and fibrous tissue, resulting from radiation therapy. The word Radionecrosi is from the ancient Greek radión (“radiated”) and nyktón (“renewal, growth, formation”).

But with radiation necrosis in the place where, under the influence of radiation, there was

Radionecrosis (NR) is the necrosis of bone and/or soft tissue that occurs after the therapeutic effects of radiobiology or radiotomy due to the absorption of radiation by these tissues or particles.

The exact reasons for the development of radiation necrosis have not been clarified, but there are several hypotheses: 1. Long-term radiation causes an increase in the permeability of cell membranes, including mitochondria. This can cause damage to the mitochondrial apparatus, which in turn leads to disruption of cellular respiration. Against this background, the functions of metabolic processes of cells are disrupted. 2. Intervention by ionizing radiation leads to an increase in the number of reactive oxygen species (ROS). ROS enter into chemical reactions, damaging

Radionecrosis

Radionecrosis is the development of tissue necrosis after a long course of radiation. This is irreversible damage to cellular structures, most often bones, which have the highest energy consumption and radiosensitivity. Moreover, up to 90% of victims suffer from neurological disorders and paresis. This pathology is of non-infectious origin; it can develop against the background of already existing chronic diseases (oncological pathologies, endocarditis