Renin-Angiotensin-Aldosterone system

The renin-angiotensin-aldosterone system (also known as the renin-angiotensin system) is an endocrine system that plays an important role in regulating blood pressure and water-salt balance in the body.

The main components of this system:

1. Renin is an enzyme produced in the kidneys that catalyzes the conversion of angiotensinogen to angiotensin I.

2. Angiotensinogen is a blood plasma protein from which angiotensin I is formed.

3. Angiotensin I is an inactive decapeptide, which under the influence of ACE (angiotensin-converting enzyme) is converted into angiotensin II.

4. Angiotensin II is an active octapeptide that has a powerful vasoconstrictor and aldosterone-stimulating effect.

5. Aldosterone is a hormone of the adrenal cortex that stimulates sodium reabsorption in the renal tubules and fluid retention in the body.

Thus, activation of the renin-angiotensin-aldosterone system leads to an increase in blood pressure due to vasoconstriction and an increase in circulating blood volume. This system is closely related to the regulation of water-salt metabolism and plays a key role in maintaining homeostasis.

The renin-aldosterone-angiotensin system is one of the most important mechanisms for regulating blood pressure in the body. This mechanism is responsible for maintaining blood pressure at a normal level regardless of external factors such as ambient temperature or physical activity. The system functions through the interaction of three different proteins, which together regulate the level of angiotensin II.