Subendothelium

Subendothelial layer

The **subendothelial** layer of anatomical formation is a layer of cells lying between the endothelium and the connective tissue or membrane, which provides support and regulation of the functions performed in relation to the cells and structures located above. Below is more detailed information about this layer and its significance in the development of pathology.

Concept of the subendothelial layer

The term "subendothelial" is used to refer to the layer of cells that lie between the endothelial cells that lie on the surface of blood vessels. Endothelial cells are variably shaped cells with dense cytoplasm, often located in superficial clusters, sometimes concentrated near a deep network of capillaries. These cells form an impenetrable barrier through which blood passes between incoming red blood cells or other blood cells and the blood vessel. If the subendothelial barrier is damaged, the destruction of endothelial cells causes a number of serious changes in immune system function and metabolism, which can potentially lead to tissue infiltration and even destruction of vital organs.