Sulfonylurea (Sulphonylurea) is a representative of the group of oral hypoglycemic drugs derived from sulfonamide, which are used to treat non-insulin-dependent diabetes mellitus. The action of these substances is based on stimulation of the islet cells of the pancreas, which leads to the secretion of more insulin. This group of drugs includes: chlorpropamide, tolazamide, glibsnclamide and tolbutamide.

Sulfonylureas

The sulfonylurea group of drugs is one of the most important classes of drugs for the treatment of type 2 diabetes mellitus. They are oral hypoglycemic drugs used to treat non-insulin-dependent diabetes mellitus (NIDDM).

The action of these drugs is based on stimulating insulin secretion by islet cells of the pancreas. This occurs due to changes in intracellular glucose levels in cells, which in turn causes an increase in insulin secretion.

Sulfonylurea drugs include chlorpropamide, tolzamide, glibenclamide and tolutamide. They all have different mechanisms of action and are used depending on the individual needs of the patient.

Chlorpropamide is the oldest drug in this group. It stimulates insulin secretion by increasing its concentration in the blood. However, it can also cause hypoglycemia, so it should be used with caution in patients with low blood glucose levels.

Tolzamide and glibenclamide are more modern drugs. Tolzamide increases insulin secretion by stimulating insulin receptors in islet cells. Glibenclamide also stimulates insulin secretion, but its action is faster and stronger than that of tolzamide.

Tolutamide is a relatively new drug. It works by inhibiting the enzyme that breaks down insulin, making it more available for use by cells. This drug can also be used to treat NIDDM, but it has a higher risk of hypoglycemia and should be used with caution.

In general, the sulfonylurea group of drugs is a very important class of drugs for the treatment of diabetes mellitus. They provide effective and safe treatment for this disease, helping patients control their blood glucose levels and improve their quality of life.

Sulfonylated ureas (sulfonylamides) are the basis for the production of hypoglycemic drugs of the sulfonylurea group. Sulfonic acid, also known as sulmic acid or simply sulfone, is one of the members of the sulfone class.