Sulfosalicylic Acid

Sulfosalicylic acid: application in the determination of proteins in biological fluids

Sulfosalicylic acid is a derivative of benzoic acid and is widely used for the determination of proteins in urine and other biological fluids. It has the ability to precipitate proteins, which makes it possible to use it in the nephelometric determination of proteins.

Nephelometric detection of proteins is based on the measurement of light scattering caused by proteins in solution. Sulfosalicylic acid precipitates proteins and reduces the amount of scattered light, which allows you to more accurately determine their concentration.

In addition, sulfosalicylic acid is widely used in clinical practice for the diagnosis and monitoring of diabetic nephropathy. This method is based on determining the concentration of albumin in urine, which is one of the most sensitive biomarkers of the disease.

However, it should be noted that the use of sulfosalicylic acid has its limitations. In particular, its use can lead to false-positive results in the determination of low molecular weight proteins and nucleic acids.

Thus, sulfosalicylic acid is an important tool for the determination of proteins in biological fluids, as well as for the diagnosis and monitoring of certain diseases. However, it is necessary to take into account its limitations and use it taking into account the specifics of the study.