Teopek

Country of origin: Russia, Borshchagovsky Chemical-Pharmaceutical Plant, Ukraine, Moskhimfarmpreparaty im. ON THE. Semashko Russia, Olainfarm Olainskiy Chemical Plant Latvia, Tatkhimfarmpreparaty Russia, Pharmapack Russia

Pharm-Group: Bronchodilators - phosphodiesterase inhibitors

Manufacturers: unspecified company (Russia), Borshchagovsky Chemical and Pharmaceutical Plant (Ukraine), Moskhimfarmpreparaty im. ON THE. Semashko (Russia), Olainfarm Olainsky Pharmaceutical Plant (Latvia), Tatkhimfarmpreparaty (Russia), Pharmapack (Russia)

International name: Theophylline

Synonyms: Afonilum SR, Ventax, Diffumal 24, Durophilin, Neoteopek A, Retafil, Slow-bid, Slow-Fillin, Spophylline retard 100, Spophylline retard 250, Theo, Teobiolong, Theodil, Theostat, Theotard, Theophylline, Theophylline anhydrous, Theophylline granulate N, Theophylline-N.S., Uni-dur

Dosage forms: tablets 300 mg, film-coated tablets 100 mg, film-coated tablets 200 mg, tablets 100 mg, tablets 200 mg, retard tablets 300 mg, extended-release tablets 300 mg

Composition: Active substance: Theophylline.

Indications for use: Bronchial asthma, status asthmaticus, obstructive bronchitis, emphysema, apnea in newborns (adjuvant).

Contraindications: Hypersensitivity, incl. and other xanthine derivatives (caffeine, pentoxifylline, theobromine), hemorrhagic stroke, retinal hemorrhage, acute myocardial infarction, severe atherosclerosis of the coronary arteries, recent history of bleeding, pregnancy, breastfeeding (stop treatment for the duration of treatment).

Side effects: Anxiety, impaired consciousness, convulsions, visual disturbances, scotoma, angina attacks, arrhythmias, tachycardia, hypotension, laryngitis, sore throat, flu-like syndrome, nasal congestion, xerostomia, anorexia, nausea, vomiting, heartburn, exacerbation of cholecystitis, cholestatic hepatitis, increased concentrations of liver enzymes (AST, ALT, alkaline phosphatase, LDH), intestinal atony, leukopenia, hypofibrinogenemia, pancytopenia, thrombocytopenia, allergic reactions.

Interaction: Cimetidine, allopurinol, cyclosporine A, macrolide antibiotics, oral contraceptives, anti-influenza serum, a diet low in protein and high in carbohydrates - reduce clearance and increase the risk of side effects. Phenobarbital, phenytoin, xanthines, smoking - accelerate biotransformation (induce microsomal liver enzymes). Beta blockers reduce bronchodilator activity. Adsorbents, enveloping agents, antacids, oxidizing agents slow down absorption and reduce Cmax, and alkalizing substances increase it. Enhances the effects of diuretics, reduces NSAIDs (from the group of pyrazolone derivatives), beta-blockers, probenecid.

Overdose: Symptoms: agitation, confusion, convulsions, tachycardia, arrhythmia, hypotension, nausea, diarrhea, vomiting with blood, hyperglycemia, hypokalemia, metabolic acidosis. Treatment: administration of activated carbon, intestinal irrigation with a combination of polyet

Special instructions: Treatment with retard forms is carried out with periodic monitoring of the concentration of the drug in the blood (should not exceed 20 mcg/ml).

Literature:

1. Encyclopedia of Medicines, 2003
2. Directory "Medicines" M.A. Klyuev, 2001