Tolerance Immunological

Immune tolerance is the inability of the body to respond to a specific antigen, while maintaining immune reactivity to other antigens. Tolerance can be natural, which is determined by the genotype of the organism, or artificial, which occurs when the antigen and immunosuppressants are administered together.

Natural tolerance is the body's ability to maintain immune reactivity to antigens that do not provoke an immune response. This occurs due to the presence of certain genes that control the immune response. For example, people who are allergic to birch pollen may have genes that allow them to maintain an immune response to other allergens, such as pollen from other plants.

Artificial tolerance occurs when antigens and immunosuppressants, such as glucocorticoids or cyclosporine, are coadministered. These drugs suppress the immune system and allow antigens to be introduced without developing an immune response to them.

Immune tolerance plays an important role in maintaining the health of the body. It allows you to maintain immune protection against certain antigens, which is important for preventing the development of autoimmune diseases and allergic reactions. However, artificial tolerance can lead to the development of infectious diseases, as it impairs the body's ability to fight infections.

Thus, immune tolerance is an important mechanism for maintaining the health of the body and preventing the development of various diseases. However, artificially creating tolerance can have negative consequences, so it is necessary to consider the risks and use this mechanism only when absolutely necessary.

Immunological tolerance is the inability of the body to respond to certain antigens while maintaining a reaction to other antigens. It can be natural, when the genome of an individual already contains information about tolerance, or artificial, when tolerance is induced by the joint administration of an antigen and immunosuppressants.

Natural tolerance can be genetically determined and transmitted from parents to offspring. For example, people who have a genetic predisposition to allergies to certain plant pollen may have children who do not react to that pollen.

Artificial tolerance occurs when antigens are administered together with immunosuppressive drugs. For example, the treatment of autoimmune diseases such as rheumatoid arthritis uses immunosuppressants, which reduce the activity of the immune system. In this case, the introduction of antigens can lead to artificial tolerance to them.

Immunological tolerance is important for human health. It allows the body to maintain an immune response to other antigens, protecting it from infections and other diseases. However, artificial tolerance can lead to undesirable consequences, such as decreased protection against infections or the development of autoimmune reactions. Therefore, it is important to consider the possible risks and carry out treatment with caution.