Toxic Threshold

The toxic threshold (synonym: harmful threshold) is the minimum dose of a substance at which toxic effects are observed.

The threshold of toxic action depends on the specific substance and the route of its entry into the body (oral, inhalation, dermal). It is established during toxicological studies on laboratory animals with subsequent extrapolation of data to humans.

Knowledge of threshold values ​​makes it possible to assess the degree of danger of toxic substances and establish hygienic standards (maximum permissible concentrations, approximately safe exposure levels, etc.). Compliance with these standards should ensure the absence of a toxic effect through a given route of entry of the substance.

Thus, the threshold of toxic action is an important toxicological characteristic that allows one to assess the danger of a substance and develop measures to protect public health.

The toxic action threshold (TEL) is the concentration of a substance in the air at which a person reacts to its exposure. PTD can be expressed in different units of measurement (for example, milligrams per cubic meter of air), and it depends on the type of substance and the characteristics of the human body.

Substances that can cause toxic effects are called toxic. These include various chemical compounds, including pesticides, industrial gases, aerosols and other substances that may be hazardous to human health.

The threshold for toxic action depends on many factors, such as age, gender, health status, individual characteristics of the body, etc. For example, for some substances the TEL may be lower for children, pregnant women, or people with certain medical conditions. Also, PTD may vary for different parts of the body, such as the skin or lungs.

When working with toxic substances, safety rules must be followed to avoid their effects on the human body. PTD is an important indicator that allows you to assess the level of danger of a substance and take measures to protect human health.