Transplantation of Syngeneic Tumors

Syngeneic tumor transplantation: what is it and how does it work?

Syngeneic tumor transplantation is a cancer treatment method in which a tumor is transplanted from one organism to another, but only if the donor and recipient are genetically identical, that is, they have the same genome. This type of transplantation is also called isogenic or isological.

The advantages of syngeneic tumor transplantation are that the tumor is transplanted into a healthy body without rejection, since the recipient's immune system does not recognize it as foreign. This avoids many of the problems associated with graft rejection that occur with other cancer treatments, such as chemotherapy or radiation therapy.

However, syngeneic tumor transplantation is not a universal method of cancer treatment, as it requires the presence of a genetically identical donor, which is a rare case. In addition, this method has certain risks, since the transplanted tumor can continue to grow and develop, causing metastases in other organs.

However, syngeneic tumor transplantation can be an effective treatment in some cases, especially in the treatment of hematopoietic malignancies such as leukemia or lymphoma. In some cases, it can also be used to study the mechanisms of cancer and develop new treatments.

In conclusion, syngeneic tumor transplantation is an innovative cancer treatment that may be effective in some cases. However, its use requires careful selection of patients and donors, as well as constant monitoring of the patient after surgery.

Syngeneic tumor transplantation

Syngeneic tumor transplantation (also syngenous or isotopic transposition) is an operation to replace an affected organ or tissue with a part of another organ of the same organism. The opposite of syngeneic transplantation is alloplasty.

Syngeneic transplantation was first described by Hippocrates, who observed cases of spontaneous rudimentary twins or duplications, when one of the halves developed completely independently and, as a result, was completely torn off from the original maternal tissue and, in the end, replaced the latter. According to Pappenheim, "The phenomenon of spontaneous bifurcation observed in the fruits of the human body does not appear to be so unusual in the animal kingdom." Hippocrates noted that such cases could be produced by placing embryonic matter from one animal in the place of the tumor of another. This technique is most widely used in gonadal transplantation to treat infertility. Now, several thousand years after Hippocrates, based on his discoveries, experiments are being conducted to create ideal artificial hybrids of humans and animals.