Verapamil

Country of origin: Russia, Akrikhin HFC (Russia), Alkaloid (Macedonia), Belupo Ltd (Croatia), Vector-Pharm (Russia), Knoll AG (Germany), World Pharmaceutical (Netherlands), Norton Healthcare Ltd (Great Britain), Obolenskoe pharmaceutical company (Russia), Serena Pharma/Shreya Life Sciences (India)

Pharm-Group: Calcium channel blockers of the phenylalkylamine group

Manufacturers: ICN October (Russia), Akrikhin HFC (Russia), Alkaloid (Macedonia), Belupo Ltd (Croatia), Vector-Pharm (Russia), Knoll AG (Germany), World Pharmaceutical (Netherlands), Norton Healthcare Ltd ( Great Britain), Obolensk Pharmaceutical Enterprise (Russia), Serena

International name: Verapamil

Synonyms: Atsupamil, Vepamil, Veracard, Veramil, Verapabene, Verapamil (Mival), Verapamil hydrochloride, Verapamil-MIK, Verapamil-Ratiopharm, Verapamil hydrochloride, Vero-Verapamil, Verogalid ER, Veromil, Danistol, Isoptin, Isoptin SR, Kaveril, Lekoptin , Falicard, Falipamil

Dosage forms: 40 mg dragees, 80 mg dragees, 80 mg film-coated tablets, 120 mg film-coated tablets, 5 mg injection solution, 80 mg tablets, 120 mg tablets, 40 mg film-coated tablets, 40 mg film-coated tablets, 40 mg film-coated tablets, 80 mg film-coated tablets

Composition: Active ingredient - Verapamil.

Indications for use: Paroxysmal supraventricular tachycardia (except WPW syndrome), sinus tachycardia, atrial extrasystole, atrial fibrillation and flutter, angina pectoris (including Prinzmetal, tension, post-infarction), arterial hypertension, hypertensive crisis, idiopathic hypertrophic subaortic stenosis, hypertrophic cardiomyopathy.

Contraindications: Hypersensitivity, severe hypotension, cardiogenic shock, AV block II and III degrees, myocardial infarction (acute or recent and complicated by bradycardia, hypotension, left ventricular failure), chronic heart failure stage III, WPW syndrome and sick sinus syndrome ( if a pacemaker is not implanted), sinoatrial block, Morgagni-Adams-Stokes syndrome, digitalis intoxication, severe aortic stenosis, pregnancy, breastfeeding. Restrictions on use: AV blockade of the first degree, chronic heart failure of stages I and II, severe bradycardia (less than 50 beats/min), mild or moderate hypotension, severe myopathy (Duchenne syndrome), impaired liver or kidney function, ventricular tachycardia with wide QRS complex (for intravenous administration).

Side effect:

1. From the cardiovascular system and blood: hypotension, bradycardia (sinus), AV block, heart failure.

2. From the nervous system and sensory organs: headache, dizziness, nervousness, lethargy, drowsiness, weakness, fatigue, paresthesia.

3. From the gastrointestinal tract: nausea, dyspeptic symptoms, constipation; rarely - gingival hyperplasia, increased activity of liver transaminases, alkaline phosphatase.

4. Allergic reactions: skin rash, urticaria, itching; rarely - angioedema, Stevens-Johnson syndrome.

5. Other: facial skin flushing, bronchospasm (with intravenous administration), peripheral edema, very rarely - gynecomastia, increased prolactin secretion.

Interaction:

1. Increases plasma levels of digoxin, cyclosporine, theophylline, carbamazepine, reduces lithium levels.

2. Weakens the effect of rifampicin, phenobarbital, potentiates the effect of muscle relaxants.

3. The hypotensive and antianginal effects are enhanced when used together with other drugs.