Vinkarelbin

Vinkarelbine: use, side effects and special instructions

Vinkarelbine is a drug that belongs to the pharmacological group of alkaloids and other cytostatic drugs of plant origin. The active substance is vinorelbine, which is produced in Argentina by Teva Pharmaceutical Enterprises, IMA Laboratories and Tutor Laboratories.

Vinkarelbine is available as a concentrate for the preparation of 10 mg/ml infusion solution. It is used to treat inoperable non-small cell lung cancer, breast cancer and ovarian cancer.

However, before using Vinkarelbine, contraindications and side effects must be taken into account. Contraindications include liver and kidney dysfunction, granulocytopenia, pregnancy and lactation.

Side effects may include granulocytopenia, anemia, nausea, vomiting, constipation, decreased osteotendon reflexes, paresthesia, weakness in the lower extremities, jaw pain, paralytic ileus, bronchospastic reactions, alopecia and phlebitis at the injection site.

Vincarelbine may also interact with other anticancer drugs such as cisplatin, enhancing their effect.

To prevent possible complications, dynamic monitoring of peripheral blood parameters and biochemical indicators of liver function is necessary.

In case of an overdose of Vinkarelbine, severe granulocytopenia with the development of neutropenic fever and superinfection may occur. In such cases, it is necessary to carry out a transfusion of a preserved mixture of granulocytes, the introduction of colony-stimulating factors to improve granulocytopoiesis, and antibacterial therapy for superinfection.

In conclusion, Vinkarelbine is a powerful anticancer drug that may be effective in treating some types of cancer. However, its use should only be carried out under the supervision of a physician and in compliance with all instructions.