Pharm-Group: Mucolytic agents
International name: Acetylcysteine
Synonyms: Acetylcysteine, Acetylcysteine Sediko effervescent instant, Acetylcysteine Stada International, Acetylcysteine-Hemofarm, ACC, ACC 100, ACC injection., ACC-100, ACC-200, ACC-long, ACC-long, Muko Sanigen, Mukobene, Mucomist, Mukonex , Tussicom, Fluimucil, Flu
Composition: Active substance - acetylcysteine.
Indications for use: Difficulty secreting sputum (bronchitis, pneumonia, bronchiectasis), bronchial asthma, cystic fibrosis, otitis, rhinitis, sinusitis, complications during operations on the respiratory system (prevention), paracetamol poisoning (as an antidote).
Contraindications: Hypersensitivity, peptic ulcer of the stomach and duodenum in the acute stage, tendency to pulmonary bleeding, hemoptysis, pulmonary hemorrhage, bronchial asthma (without thickening of sputum), diseases of the liver, kidneys, adrenal glands, pregnancy.
Side effects: Heartburn, nausea, vomiting, tinnitus, urticaria.
Interaction: Increases (mutually) the effect of bronchodilators. Reduces the absorption of penicillins, cephalosporins, tetracyclines (the interval between doses should be at least 2 hours). Pharmaceutically incompatible with antibiotics and proteolytic enzymes; upon contact with metals and rubber, it forms sulfides with a characteristic odor.
Overdose: No information.
Special instructions: In patients with broncho-obstructive syndrome (develops quite often against the background of increased bronchospasm), acetylcysteine must be combined with bronchodilators. Do not allow contact with metals, rubber, oxygen, or easily oxidized substances.
Literature: Encyclopedia of Medicines, 10th edition, 2003.