Adler's granules are small collections of lymphoid tissue located in the lining of the uterus (endometrium). They were first described by the Austrian gynecologist Alfred Adler in 1908.
Adler's granules are lymphoid tissue consisting of B lymphocytes. They are located mainly around the glands and vessels of the basal layer of the endometrium. The number of Adler granules is maximum in the secretory phase of the menstrual cycle.
The function of Adler granules is the immune protection of the uterine cavity. They produce immunoglobulins and other humoral immune factors, and are also the site of activation of T lymphocytes. Adler granules are involved in the immune response to pathogenic microorganisms, as well as in the processes of fertilization and embryo implantation.
In some pathological conditions, such as chronic endometritis, the number and size of Adler granules increase. This is considered a compensatory reaction in response to inflammation.
Thus, Adler granules play an important role in maintaining endometrial immunity and the normal course of reproductive processes in women. Their study is important for understanding the pathogenesis of gynecological diseases and developing new methods for their diagnosis and treatment.