Amphotericin B Ointment

Amphotericin B ointment

Country of origin - Russia, Synthesis AKO, Kurgan Russia
Pharm-Group - Antibiotics for the treatment of fungal diseases

Manufacturers - Biokhimik (Russia), Synthesis AKO, Kurgan (Russia)
International name - Amphotericin B
Synonyms - Ambizom, Ampholip, Amphotericin B, Amphocil, Fungizone, Fungilin
Dosage forms - ointment 30000IU/g
Composition - Active ingredient - Amphotericin B.

Indications for use:

1. Systemic mycoses - candidomycosis, aspergillosis, histoplasmosis, cryptococcosis, coccidioidomycosis, blastomycosis, pulmonary mycoses (actinomycosis), cystitis, leishmaniasis.

Contraindications:

1. Hypersensitivity, severe liver and kidney dysfunction, diseases of the hematopoietic system, diabetes mellitus, breastfeeding.
2. Restrictions on use: Pregnancy.

Side effect:

1. From the nervous system and sensory organs: headache, polyneuropathy, blurred vision, diplopia.
2. From the cardiovascular system and blood (hematopoiesis, hemostasis): arterial hypo- or hypertension, arrhythmia, ECG changes, anemia, leukopenia, thrombocytopenia.
3. From the gastrointestinal tract: nausea, vomiting, diarrhea, epigastric pain, decreased appetite, increased activity of liver enzymes.
4. From the genitourinary system: impaired renal function, incl. increased serum creatinine concentration, proteinuria, azotemia, acidosis.
5. Allergic reactions: skin rash, itching, Quincke's edema, bronchospasm (during inhalation).
6. Other: increased body temperature, chills, disturbances in the electrolyte composition of the blood, incl. hypokalemia, hypomagnesemia; thrombophlebitis at the injection site; during inhalation - sore throat, cough, runny nose; when applied topically, allergic reactions are possible.

Interaction:

1. May enhance the effect of cardiac glycosides and curare-like muscle relaxants.
2. Incompatible with nephrotoxic antibiotics and antitumor drugs.

Overdose:

1. Symptoms: increased side effects, possible cardiac and respiratory arrest.
2. Treatment: symptomatic.

Special instructions:

1. During treatment, systematic monitoring of kidney function, liver function, blood composition and potassium levels in the blood is necessary.
2. If symptoms of anemia appear, treatment with amphotericin B should be discontinued.

Literature:

1. Encyclopedia of Medicines 2004