Amoklavin

Amoklavine: a combined antimicrobial agent

Amoklavin is a combined antimicrobial agent produced by the Turkish company Deva Holding. It combines two active ingredients: amoxicillin and clavulanic acid. Amoxicillin belongs to the group of semisynthetic penicillins, and clavulanic acid belongs to the beta-lactamase inhibitors.

Amoklavin is marketed under various trade names, including Amoxiclav, Augmentin, Clavocin, Clavunat, Medoclav, Moxiclav, Panclave, Ranclave and Flemoclav Solutab. It is available in several forms, including 625 mg film tablets, powder for oral suspension forte 312.5 mg/5 ml and powder for oral suspension for children 156 mg/5 ml.

Amoclavine is used to treat a wide range of infectious diseases, including upper and lower respiratory tract infections, urinary tract infections, gynecological infections, biliary tract infections, bone and connective tissue infections, skin and soft tissue infections, odontogenic infections and sexually transmitted infections.

Amoclavine is not recommended for use in cases of hypersensitivity to penicillin and cephalosporin antibiotics, as well as in the presence of cholestatic jaundice, hepatitis caused by a history of taking penicillin antibiotics, liver failure and infectious mononucleosis or lymphocytic leukemia.

When using Amoklavin, some side effects may occur, such as loss of appetite, nausea, vomiting, diarrhea, superinfection, stomatitis, vaginitis, allergic reactions, including itching and skin rashes, as well as immediate hypersensitivity reactions, including anaphylactic shock. In rare cases, cholestatic jaundice, hepatitis and liver dysfunction may occur.

With simultaneous use of Amoklavin with methotrexate, the toxicity of methotrexate increases, with allopurinol - the incidence of exanthema, and with anticoagulants - the prothrombin time is prolonged. The effectiveness of oral contraceptives decreases. Concomitant use with disulfiram should be avoided. The combination of Amoclavine with bacteriostatic antibiotics, such as macrolides and tetracyclines, may reduce the effectiveness of Amoclavine.

The dosage of Amoklavin depends on the type and severity of the infection, as well as the age and weight of the patient. The generally recommended dose for adults and children over 12 years of age is 625 mg twice daily. For children aged 3 months to 12 years, the recommended dose depends on weight and ranges from 20 to 90 mg/kg body weight per day, divided into two or three doses.

Overall, Amoclavine is an effective and widely used antimicrobial agent for the treatment of various infectious diseases. However, as with any antibiotic, you must strictly follow the instructions for use and consult your doctor before starting to use it.