Anesthesia

Anestezin is a drug that has a selective hematotoxic effect due to the ability to cause methemoglobinemia.

In case of an overdose of anesthesin, severe cyanosis of the lips, ears, face, and limbs develops due to acute methemoglobinemia. Psychomotor agitation is observed.

With methemoglobinemia of more than 50%, the development of coma, hemolysis, and exotoxic shock is possible. There is a high risk of developing anaphylactic reactions, especially in children.

Treatment of anesthetic intoxication includes:

1. Gastric lavage, forced diuresis with blood alkalization.

2. Introduction of methylene blue, ascorbic acid.

3. Oxygen therapy, hyperbaric oxygenation.

4. Administration of thiamine and pyridoxine.

Country of origin: Russia, ICN October Russia, Organika Russia

Pharm-Group: Local anesthetics

Manufacturers: ICN Marbiopharm (Russia), ICN October (Russia), Organika (Russia)

International name: Benzocaine

Synonyms: Anastezin-UVI, Anestezin-UVI, Anesthetic ointment, Bartel Drugs anesthetic gel for lips and oral mucosa, Benzocaine, Dentisprey

Dosage forms: tablets 300 mg, substance

Composition: Active ingredient - Benzocaine.

Indications for use: Orally - gastralgia, increased sensitivity of the esophagus; locally - acute inflammation of the middle ear, pain in the external auditory canal, urticaria, skin diseases accompanied by itching, anal fissures, hemorrhoids. Performing diagnostic manipulations on the mucous membranes (gastroscopy, rectoscopy, otoscopy, urethroscopy, gynecological procedures).

Contraindications: Hypersensitivity. Restrictions on use. Breastfeeding (should be suspended), infancy (up to 1 year).

Side effects: Contact dermatitis, persistent decrease in sensitivity at the site of application, allergic reactions.

Interaction: No data available.

Overdose: Characterized by methemoglobinemia, respiratory distress syndrome, cyanosis. Treatment: symptomatic and intravenous administration of methylene blue.

Special instructions: No data available.

Literature: Encyclopedia of Medicines 2004. Directory Medicines M.D. Mashkovsky 14th edition.