Anti-complementarity

Anticomplementarity is the property of some substances, such as lipoproteins, to activate the complement system without the participation of specific antibodies.

The complement system is a cascade of plasma proteins that are activated sequentially to enhance the immune response. It is usually triggered when antibodies bind to an antigen.

However, some substances, in particular low-density lipoproteins, are capable of directly activating components of the complement system, bypassing the stage of binding to antibodies. This phenomenon is called anti-complementarity.

The anticomplementary activity of lipoproteins is determined by their composition and structure. They contain phospholipids and apolipoproteins that can interact with complement proteins.

Studying the anticomplementary properties of various substances is important for understanding the mechanisms of immunity regulation and developing new approaches to immunotherapy.

The anti-complementary property of some lipoprotein structures is important in the development and pathogenesis of many diseases. For example, complexes of antigens and antibodies, which are secretory immunoglobulins G, activate the complement system and can participate in autoimmune reactions. Other lipoprotein structures, especially from the class of microphospholipids, capture plasma cells and cause them to produce antibodies with the property of starting the blood clotting process. At the same time, various microphospholipids are components of the cytoskeleton necessary for the strength of the cell membrane. These unique structures remain in place until they themselves become a kind of antibodies, as they attack and damage the antigens that we consider as “good” (xenoblasts

Anti-complementarity is the specific property of some lipoprotein substances to activate killer cells of the complement system without using specific antibodies (components of the classical pathway of complement activation).

In the human body, a close connection has been discovered between the blood system and lymphoid tissue. The result of intercellular integration is the creation of the so-called integrated immune system. In addition to antigens,