Country of origin: Cyprus
Pharm-Group: Anti-inflammatory drugs of different groups
Manufacturers: Medokemi Ltd (Cyprus)
International name: Nimesulide
Synonyms: Aktasulide, Kokstral, Mesulide, Nise, Nimegesik, Nimesil, Nimika, Nimulid, Prolid, Flolid
Dosage forms: tablets 100 mg
Composition: Active substance - nimesulide.
Indications for use: Osteoarthritis, osteoarthritis, bursitis, tendinitis, pain and inflammatory processes (in case of injuries, in the postoperative period, gynecological and infectious-inflammatory diseases). Nise gel: inflammatory and degenerative diseases of the musculoskeletal system (articular syndrome with rheumatism and exacerbation gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory damage to ligaments, tendons, bursitis, sciatica, lumbago). Muscle pain of rheumatic and non-rheumatic origin. Post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises).
Contraindications: Hypersensitivity, peptic ulcer of the stomach and duodenum in the acute stage, severe dysfunction of the liver and kidneys, bleeding from the gastrointestinal tract, type 2 diabetes mellitus, arterial hypertension, congestive heart failure, pregnancy, lactation. Restrictions for use: children's age (up to 12 years old).
Side effects: Headache, dizziness, drowsiness; very rarely - thrombocytopenia; nausea, heartburn, stomach pain, tarry stools, melena; petechiae, purpura; oliguria; allergic reactions (exanthema, erythema, urticaria). Nise gel: Local reactions: itching, urticaria, peeling, transient change in skin color (not requiring discontinuation of the drug). If any adverse reactions occur, you should stop using the drug and consult your doctor. When applying the gel to large areas of the skin, the development of systemic adverse reactions cannot be ruled out: heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of the gastrointestinal mucosa, increased activity of “liver” transaminases; headache, dizziness; fluid retention, hematuria; allergic reactions (anaphylactic shock, skin rash); thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.
Interaction: May increase the effectiveness and toxicity of many drugs, due to their displacement from sites of binding to plasma proteins and an increase in the free fraction in the blood (with the simultaneous administration of hydantoin and sulfonamides, regular medical supervision is required). Enhances the effect of medications that reduce blood clotting; increases plasma lithium levels.
Overdose: Symptoms: increased severity of side effects. Treatment: gastric lavage, administration of activated carbon.
Special instructions: Prescribe with caution to elderly patients, with cardiovascular diseases, including arterial hypertension, tendency to bleeding, disorders of the upper gastrointestinal tract, impaired renal function, during treatment with anticoagulants and antiplatelet agents. If visual disturbances occur, you should immediately stop taking the drug and consult an ophthalmologist. Patients with diabetes mellitus and patients on a low-calorie diet should take into account that the drug contains sucrose. Prescribe with caution to patients whose work requires increased attention and reaction speed.
Literature: Encyclopedia of Medicines 2001. Encyclopedia of Medicines 2005.