Aspen

Country of origin: Austria, Krka Slovenia, Krka d.d. Slovenia
Pharm-Group: Antibiotics of the penicillin group

Manufacturers: Biochemi GmbH (Austria), Krka (Slovenia), Krka d.d. (Slovenia)
International name: Benzathine phenoxymethylpenicillin
Synonyms: Ospen 750, Ospen-750 syrup
Dosage forms: drops 4500000IU, syrup 750000IU/5ml, tablets 250mg, tablets 500mg, film-coated tablets 1g, film-coated tablets 1.5g, syrup 400mg/ml, granules for the preparation of oral solution 400mg/ml, drops 150000IU/ml, granulate for preparation oral solution
Composition: Tablets - active substance phenoxymethylpenicillin. Granules, syrup - active substance benzathine phenoxymethylpenicillin.

Indications for use: Infections of the upper and lower respiratory tract (bronchitis, bronchopneumonia), ENT organs (tonsillitis, pharyngitis, laryngitis, otitis media, sinusitis), skin and soft tissues (erysipelas, contagious impetigo, erysipeloid, erythema migrans, furunculosis, abscess , phlegmon), oral cavity (pericoronitis, periodontitis, bacterial stomatitis, actinomycosis); botulism, scarlet fever, leptospirosis, prevention of bacterial infections after surgery in weakened patients, relapses of rheumatism, rheumatoid arthritis, bacterial endocarditis, glomerulonephritis, chorea minor.

Contraindications: Hypersensitivity (including to other penicillins, cephalosporins, carbapenems), acute stage of severe pneumonia, empyema, pericarditis, arthritis, gastrointestinal diseases accompanied by vomiting and diarrhea.

Side effects: Anorexia, nausea, vomiting, flatulence, diarrhea, dry mouth, taste disturbance, glossitis, stomatitis, vesicular cheilitis, interstitial nephritis, vasculitis, granulocytopenia, leukopenia, agranulocytosis, thrombocytopenia, eosinophilia, hemolytic anemia, pancytopenia, superinfection, pseudomembranous colitis, allergic phenomena: skin reactions (itching, urticaria, exanthema), bronchospasm, serum sickness, angioedema, anaphylactic shock.

Interaction: Bacteriostatic chemotherapeutic agents reduce the effect. Neomycin interferes with absorption, NSAIDs (indomethacin, phenylbutazone, salicylates) reduce excretion, increasing activity and toxicity. When combined with allopurinol, phenylbutazone, NSAIDs, calcium secretion decreases and the concentration of phenoxymethylpenicillin increases. Increases the effectiveness of anticoagulants by suppressing intestinal microflora and lowering the prothrombin index, weakening the effect of oral contraceptives taken.

Overdose: No data.

Special instructions: Use during pregnancy only if the benefit/risk ratio is in favor of benefit. In case of allergic reactions, stop taking. For suspected staphylococcal infections, conduct bacteriological studies. Before planned operations, double the dose. Monitor blood composition, liver and kidney functions. Growth of resistant microorganisms and fungi is possible. Use with caution for allergies and bronchial asthma. Consider the presence of synthetic saccharin in syrup in patients with diabetes mellitus.

Literature:

1. Register of Medicines 2003.