Azafen

Azafen: a neuronal uptake inhibitor for the treatment of depression

Azafen is a drug from the group of antidepressants intended for the treatment of endogenous and exogenous depression, as well as depressive conditions that occur in chronic somatic diseases. The active substance is pipofezin. Dosage form - 25 mg tablets and substance.

Azafen is produced by several pharmaceutical companies in Russia, including Akrikhin HFC, Biological Research and Systems, Makiz-Pharma and Moskhimfarmpreparaty im. ON THE. Semashko.

The drug is a non-selective neuronal uptake inhibitor, which means it blocks the uptake of the neurotransmitters serotonin, norepinephrine and dopamine into nerve endings. This leads to an increase in the concentration of these substances in the synaptic cleft and increased neurotransmission.

Azafen has a number of contraindications, including hypersensitivity to the drug, hepatic renal failure, heart failure, myocardial infarction, coronary heart disease, conditions after acute cerebrovascular accident, severe infectious diseases and diabetes mellitus. Side effects may include headache, dizziness, nausea, vomiting and allergic reactions.

Azafen's interaction with other drugs may also be unfavorable. Thus, the drug enhances the effects of alcohol and other drugs that depress the central nervous system, antihistamines and anticoagulants, and reduces the effectiveness of anticonvulsant therapy.

Restrictions on the use of Azafen are related to its safety during pregnancy and lactation. It is also not recommended to use the drug in children. Concomitant use with antidepressants-MAO inhibitors is contraindicated.

Overall, Azafen is an effective treatment for depression, but requires caution in use due to possible side effects and interactions with other drugs. Before starting to use Azafen, you should consult your doctor and strictly follow his recommendations.