Bacillus Calmette

Introduction

Bacillus Calmette was discovered in the mid-20th century by the French microbiologist A.-F. Calmette and American biotechnologist N. Guerena. It was obtained from cells of the surface layer of the lungs of mouse embryos subjected to tamurase - an extract of the thermolabile filtrate of Staphylococcus bacillus, which destroys the cell wall of sensitive bacteria. Tamurase can quickly produce multiple pure microbial cultures without tedious microcopying. There are several varieties of the Calmet bacillus: M. vaccae strain 8085 or “bacillus B”, M. flavescens strain K, M. chocolovenis strains A or C.

Description

Bacillus calmette – germane (BCG) is the causative agent of a specific infection, not found in nature. The microorganism is selected for the BCG vaccine, but its distribution is more controlled than the cultivation of Salmonella typhoid to detect dysentery, as reflected in the name. From an artificially created culture, for the specific prevention of syphilis, a hamonic vaccine is used according to the 0-1-2-3 scheme. Treatment with the BCG vaccine is developed to combat malaria. Thus, during the epidemic in India, a certain Z. R. Aiyars used a scheme of 0.47 times for five weeks. BCG can also be used to treat tuberculosis and HIV infection. As a specific drug, the immune system is treated for tuberculous mycobacterium infection. Scientists are waiting for the emergence of these strains with polymorphism of properties in order to grow the BCG vaccine from the pathogen. But for now, researchers are working with live strains in the dormant stage. Ag proteins produced by BCG have strong allergic activity, causing an acute tuberculinic process. According to some data, strains with atypical properties showed high anti-tuberculin activity (34%), which has not yet found its application. It is also capable of causing specific inflammation, exhibiting a histamine reaction; sepsis after injections. People with hypersensitivity to protein drugs should take into account the possibility of an allergy to lipopolysaccharide in the Calmette and Hernade strain. With bacteria from anthrax infection, cases of favorable cure of bullous-pustular diseases after BCG vaccination were observed. Those taking chemotherapy drugs should be able to carry anti-TB medication with them. Vaccination with BCG while taking a drug that reduces the chances of success of therapy should be carried out with a preliminary examination by a therapist, immunologist