Bactinor

Country of origin - India
Pharm-Group - Antimicrobials - fluoroquinolones

Manufacturers - Sun Pharmaceutical Industries Ltd (India)
International name - Norfloxacin
Synonyms - Anquin, Girablok, Quinolox, Loxon 400, Loxon-400, Negaflox, Nolitsin, Norbaktin, Norilet, Normax, Noroxin, Norflox, Norfloxacin, Renor, Sophasin, Spectrama, Chibroxin, Yutibid
Dosage forms - tablets 400 mg
Composition - Active substance - Norfloxacin.

Indications for use - Urinary tract infections (cystitis, pyelonephritis, urethritis, uncomplicated gonorrhea), genital infections (prostatitis, endometritis, cervicitis). Gastrointestinal tract (salmonellosis, shigellosis, traveler's diarrhea), eyes; prevention of infections in patients with granulocytopenia.

Contraindications - Hypersensitivity, end-stage chronic renal failure, glucose-6-phosphate dehydrogenase deficiency, pregnancy, lactation, children and adolescents under 15 years of age.

Side effect - Dyspeptic syndrome (anorexia, nausea, vomiting, bitterness in the mouth, abdominal pain, diarrhea), dysfunction of the urinary system (glomerulonephritis, dysuria, polyuria, proteinuria, urethral bleeding, etc.), central nervous system (headache, dizziness, insomnia, hallucinations, fainting), cardiovascular system (heart rhythm disturbances, arterial hypotension), visual organs (burning and pain in the eye, conjunctival hyperemia, chemosis, photophobia), musculoskeletal system (tendinitis, tendon ruptures, arthralgia), vasculitis, pseudomembranous colitis, dysbiosis, candidiasis, Steven-Johnson syndrome, leukopenia, eosinophilia, decreased hematocrit, transient increase in liver enzymes in the blood serum, allergic reactions (itching, urticaria, edema).

Interaction - Simultaneous use of antacids containing aluminum or magnesium hydroxide, as well as preparations containing iron and zinc, slows down absorption. The appointment interval between them is at least 3 hours. Reduces the clearance of theophylline by 25%, increases the concentration in the blood of indirect coagulants, cyclosporine. Simultaneous administration with medications that have the ability to lower blood pressure can cause severe hypotension, and with drugs that lower the convulsive threshold of the brain - epileptiform seizures. Reduces the effect of nitrofurans.

Overdose - Symptoms: dizziness, nausea, vomiting, drowsiness, cold sweats, convulsions. Treatment: gastric lavage, adequate hydration therapy with forced diuresis, prescription of symptomatic medications.

Special instructions - Do not use for atherosclerosis of cerebral vessels, cerebrovascular accident, epilepsy and convulsive syndrome, impaired renal and liver function. During the treatment period, patients should receive a sufficient amount of fluid. Monitoring of the state of the coagulation system is required. With the simultaneous administration of barbiturates and anesthetics, heart rate, blood pressure, and ECG indicators should be monitored.

Literature - Encyclopedia of Medicines 2002 issue 9, Directory "Medicines" Mashkovsky M.D. ed. No13.