Baneocin powder on an open wound

Wound healing powder Baneocin is an antiseptic that is used to accelerate the process of epithelial restoration and prevent complications. The complex drug is active against various types of opportunistic and pathogenic flora. It is used topically, strictly according to the instructions and after consultation with a specialist.

Properties of the drug Baneocin and its composition

The main components of the drug are bacitracin zinc and neomycin. The powder is used for local treatment of open wound surfaces and healing.

Effect of the drug Baneocin:

  1. Bacitracin zinc is a polypeptide antibiotic. Active against gram-positive bacteria. Suppresses staphylococcus, streptococcus, clostridia, treponema, corynebacteria. The powder affects some gram-negative microorganisms, including actinomycetes and fusobacteria. Resistance to bacitracin is rare.
  2. Neomycin is an aminoglycoside antibiotic that promotes healing. It has a bactericidal effect and destroys the bacterial cell. Aggressive against the vast majority of microorganisms. Resistance practically does not develop.

Active substances enhance each other. This promotes healing of the damaged surface.

When treating a wound, the absorption of Baneocin is minimal - it does not have a systemic effect on the body. The use of a dosage form for local application prevents the development of system-wide side effects and addiction to the drug.

Release form of Baneocin and the advantages of each of them

The products are available in 2 types. The dosages of active substances in them are the same.

The ointment is yellowish, of uniform consistency. A complete analogue of the powder in composition and quantity of active ingredients.

The indication for use is the presence of lesions infected with pathogenic flora and the acceleration of their healing.

The ointment helps soften tissue; it is advisable to prescribe it to patients with wounds that heal with secondary intention.

Baneocin powder is yellowish, reminiscent of powder or powder. This dosage form is mainly used for healing of weeping wounds and sutures, when treating areas covered with mucous membrane, such as the perineum.

The drugs in both dosage forms have a bactericidal effect. Used to heal various types of damage. The choice of the type of remedy is the prerogative of the doctor.

How to use the powder correctly

For purulent wounds and other injuries, Baneocin is applied in powder form 2-4 times a day, in the form of an ointment - 2-3 times a day. If necessary, the tissues are pre-treated with a solution of hydrogen peroxide. This allows you to remove remaining pus and impurities.

Powder the affected surface with the product. The total volume of tissue treated should not exceed an area equal to the size of the patient's palm. According to indications, after the procedure the wound is covered with a sterile bandage for healing.

The duration of the course is 7 days. If there is no effect, adjustment of treatment is recommended.

How to treat an umbilical wound

The powder is approved for use in children during the neonatal period. The drug is used only according to indications and in agreement with the pediatrician. In most cases, it is enough to use less serious antibacterial drugs to heal the navel.

The use of Baneocin for treatment is advisable:

  1. if the wound does not heal for a long time;
  2. the navel becomes wet, crusts form;
  3. the appearance of an unpleasant odor;
  4. the presence of purulent masses in the wound during healing;
  5. general poor condition of the baby, indicating an inflammatory process in the navel.

The pediatrician explains the procedure for treating with an antibacterial drug. Wound powder Baneocin is approved for healing the navel in the first days of a child’s life.

Standard rules for purulent wounds:

  1. Wash your hands, remove the diaper.
  2. Wash your stomach with boiled water at room temperature. The use of baby soap is allowed.
  3. Treat the navel with hydrogen peroxide. Blot off excess.
  4. Sprinkle the powder on the affected area.
  5. If possible, leave the child without a diaper or clothes. Allow the skin to absorb the healing agent.

The number of wound treatments with Baneocin is prescribed by the doctor. The standard recommendation in the instructions is 2–5 times a day. The duration of treatment should not exceed 7 days.

Does using Baneocin powder cause scars?

Powder and ointment are intended for the treatment of purulent, weeping surfaces. When pathogenic organisms are activated, the intensity of inflammation increases, and foci of necrosis may form. A long purulent process contributes to extensive tissue destruction, which ends in the formation of unaesthetic scars.

Surface cleanliness increases the rate of granulation, epithelialization and healing. The risk of coarse scar tissue formation is reduced.

Patient reviews of powder for injured skin areas do not mention that Baneocin on an open wound leads to scars. Users write about the rapid subsidence of the inflammatory process and suppuration.

Doctors' opinions about the drug are positive. Experts note the high speed of cleaning from necrotic tissue, ease of use, and a minimum of patient suffering during treatment and treatment. The components of the powder do not contribute to the formation of keloid scars. The formation of large sutures after the use of Baneocin for wound healing is not found in the medical literature.

Contraindications and possible complications

It is prohibited to prescribe Baneocin powder or ointment:

  1. if you have had an allergic reaction in the past to components of the drug or other aminoglycoside antibiotics;
  2. Patients with extensive wounds have kidney disease. The active substances are absorbed and have a nephrotoxic effect;
  3. severe muscle weakness;
  4. with blood acidification during healing;
  5. patients with perforation of the tympanic septum;
  6. closed wounds and sutures after surgical treatment.

Possible complications arise when using the drug independently. Baneocin has nephro- and ototoxic effects. It manifests itself with significant absorption of the active components of the powder or ointment. Increased absorption occurs with extensive damage and prolonged use of the drug for healing.

Baneocin is prescribed for the treatment of purulent, weeping lesions. There is no need to treat abrasions or pimples with it. In this case, you can use less active agents with fewer contraindications. A doctor must prescribe a drug for wound healing.

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Release forms and composition

The range of therapeutic effects of Baneocin ointment and powder

The antibiotics neomycin and bacitracin as the active ingredients of the drug Baneocin give both the ointment and the powder a bactericidal effect. Both antibiotics enhance each other's effects. This means that Baneocin is able to effectively kill microorganisms present on the skin or wound surfaces. Thus, the main therapeutic effect of the drug is the cure of infectious and inflammatory skin lesions that are caused by microorganisms sensitive to the components of the ointment and powder.
The drug Baneocin effectively destroys the following types of microorganisms:
1.Gram-positive bacteria :

  1. streptococci (Streptococcus spp., Streptococcus faecalis), including hemolytic streptococcus;
  2. staphylococci (Staphylococcus spp.);
  3. clostridia (Clostr > Fungi: actinomycetes (Actinomyces spp.).
    3.Gram-negative bacteria :
  1. neisseria (Neisseria spp., Neisseria meningitidis), including the causative agent of gonorrhea;
  2. hemophilus influenzae (Haemophilus influenzae);
  3. fusobacterium (Fusobacterium spp.);
  4. proteus (Proteus spp.);
  5. enterobacteria (Enterobacter aerogenes);
  6. Klebsiella pneumoniae;
  7. salmonella (Salmonella spp.);
  8. shigella (Shigella spp.);
  9. cholera vibrio (Vibrio cholerae);
  10. E. coli (Escherichia coli);
  11. mycobacterium tuberculosis (Mycobacterium tuberculosis);
  12. borrelia (Borellia spp.);
  13. Leptospira interrogans.

Baneocin can be used without fear that addiction will occur and resistant strains of bacteria will form. Resistance to this drug almost never develops, which makes it highly effective. The ointment and powder do not lose their pronounced antibacterial properties when they come into contact with blood or other biological fluids.

Baneocin ointment or powder is successfully used to treat various infectious and inflammatory diseases that are caused by microorganisms sensitive to the active components of the drug. Basically, Baneocin ointment is effective in treating:

  1. pustular skin lesions (boils, carbuncles);
  2. purulent infections (hidradenitis, folliculitis, pyoderma);
  3. abscesses;
  4. to prevent the development of infectious inflammation after surgical interventions (for example, puncture of the earlobe, navel, etc.).

The ointment perfectly eliminates the source of infection (microorganism), accelerates wound healing and reduces the severity of the inflammatory process. Thanks to these properties, Baneocin can be used to treat burns.

Baneocin powder is also effective for treating infections localized on the surface of the skin. The drug is successfully used for chickenpox, herpetic rashes, ulcers and eczema, as well as for treating the navel in newborns, postoperative sutures, including postpartum injuries (perineal rupture, etc.). Baneocin powder also has powerful antibacterial properties, which allows you to destroy the causative agent of infection, accelerate the healing of wounds and traumatic skin injuries, and also reduce the severity of inflammatory processes.

Indications

The scope of application of Baneocin is quite wide - the drug is used in dermatology, gynecology, pediatrics and otolaryngology. Powder and ointment have different physical properties, so they are used to treat different infections.

Indications for the use of Baneocin powder in various fields of medicine are shown in the table:

Medical field Powder - indications for use Ointment - indications for use
Dermatology Treatment and prevention of pustules, pimples Not severe infections of the skin and mucous membranes - contagious impetigo, boils and carbuncles
Treatment and prevention of infection of small wound surfaces Folliculitis and deep folliculitis on the scalp
Treatment of wounds and small surgical incisions and punctures (ear lobes, navel, scar excision, cauterization, skin grafts, cracks, weeping wounds, etc.) Hidradenitis suppurativa (inflammation of the lymph node)
Treatment of burns Sweat gland abscesses (pseudofurunculosis)
Treatment of infections of traumatic wounds (scratches, cuts, etc.) Abscesses on the skin
Treatment of blisters on the skin due to chickenpox or herpetic infection Paronychia
Infected trophic ulcers with varicose veins Ecthyma
Eczema Pyoderma (multiple pustular skin lesions)
Infection of dermatoses (eczema ulcers, etc.)
Treatment of infection and its prevention in case of traumatic, surgical or cosmetic damage to the skin (burn, skin graft, ear piercing, cuts as a result of trimmed manicure, etc.)
Infected trophic ulcers with varicose veins
Gynecology Treatment of perineal tears or incisions (episiotomy) Treatment of perineal tears
Treatment of mastitis with drainage Use in laparotomy (operations involving opening the abdominal cavity)
Prevention of mastitis Treatment of perineal incisions (episiotomy)
Treatment of mastitis with drainage
Prevention of mastitis
Otolaryngology Treatment of secondary infections in acute and chronic runny nose
Treatment of external otitis
Prevention of infection after surgery on the sinuses, forehead or mastoid process
Pediatrics Treatment of the umbilical wound to prevent infection
Treatment of diaper dermatitis

Instructions for use

Children and adults should apply ointment or powder locally, strictly to the infected area. You can simply apply the ointment to the affected area or sprinkle it with Baneocin powder, or you can cover the treated area with a bandage on top. Treat the affected areas with Baneocin ointment two to three times a day, and sprinkle with powder 2-4 times a day.

If burns that cover more than 20% of the body surface are being treated, treatment with Baneocin powder is carried out once a day. This limitation is due to the possibility of absorption of the drug into the bloodstream. However, during the use of the drug, not a single case of overdose was registered.

When treating with Baneocin, there is a maximum allowable dose, which is 1 g of active substance per day, which corresponds to 200 grams of powder or ointment. At these dosages of Baneocin, the course of treatment is 1 day. If, after using the ointment or powder in maximum doses, a second course of treatment with Baneocin is necessary, then the permissible dosages are halved. Treatment in excess of the specified maximum dosages can lead to the absorption of large amounts of Baneocin into the blood, which is fraught with a high risk of toxic damage to the kidneys and ear. Therefore, therapy with large doses of ointment or powder should be carried out under supervision, with careful monitoring for the presence of symptoms of kidney or ear damage.

In the presence of liver or kidney pathology, including their failure, Baneocin therapy increases the risk of toxic damage to these organs. That is why, during therapy, it is necessary to regularly monitor the person’s condition by doing blood and urine tests, as well as hearing tests.

Baneocin ointment must be applied to turundas when treating infections of the external auditory canal (otitis externa), large wounds and incisions that will heal with the formation of a scar. In this case, the ointment is applied to a cotton swab, which is inserted into a cavity (for example, an ear) or into a wound. When applying Baneocin, make sure that the drug does not get into your eyes. Long-term treatment of otitis with ointment significantly increases the risk of developing toxic ear lesions.

A long period of use of Baneocin ointment or powder can provoke the development of fungal infections, which requires the use of additional medications.

If an allergy develops or another infection occurs while using Baneocin, then use of the drug should be discontinued.

Interaction with other drugs

The use of Baneocin together with narcotic and non-narcotic painkillers, as well as muscle relaxants (drugs that relax muscles) can lead to the development of temporary paralysis due to disruption of the transmission of nerve impulses to the muscles.

Baneocin during pregnancy

Baneocin ointment and powder contain antibiotics that can be absorbed into the blood in small quantities. However, once in the bloodstream, Baneocin antibiotics are able to penetrate through the placenta to the fetus. Therefore, the use of ointment or powder during pregnancy and breastfeeding should be careful. The decision to use Baneocin by a pregnant or lactating woman should be made only when the benefits significantly outweigh the expected risks.

Pregnant and lactating women should not treat large areas of skin with Baneocin, since when absorbed, aminoglycosides in the ointment or powder can lead to the development of pathology of the cochlear apparatus of the inner ear of the fetus. If the drug is applied to the chest area, then before feeding the baby it is necessary to wash off the drug from the surface of the skin.

Baneocin for newborns - navel treatment

Baneocin powder can be used to treat the umbilical wound of a newborn baby from the first day of life. The effectiveness of Baneocin powder is very high; the umbilical wound heals within 2 to 5 days. The powder can be used to treat the native wound and to treat a weeping or festering umbilical stump.

To treat a normal umbilical wound, you need to sprinkle it with Baneocin powder twice a day. Pre-rinse the umbilical wound with 3% hydrogen peroxide, dry it with a cotton swab or cotton swab, and pour Baneocin powder directly into the wound. The treatment is carried out for 3 – 5 days, until the umbilical wound is completely healed and dried.

If the umbilical wound festers, becomes wet and does not heal, then treatment with Baneocin can be carried out up to 4 - 5 times a day. In this case, it is also necessary to first wash the wound with 3% hydrogen peroxide, dry it with a cotton swab or swab, then sprinkle it with Baneocin powder. Carry out the treatment as needed: after treating the wound, leave it, and when weeping or pus appears again, again carry out all the manipulations of cleaning with peroxide, drying with cotton wool and sprinkling with Baneocin powder. Usually, even a festering wound heals within 3 to 5 days, but the powder can be used for a week.

In principle, Baneocin powder should be in your child’s home medicine cabinet. The drug perfectly helps to heal wounds, scratches, cuts, bites, calluses, skinned knees and elbows (a constant occurrence in children). If a child is burned, the damaged area can also be sprinkled with powder, which will significantly speed up recovery. Baneocin powder will successfully replace iodine, brilliant green and alcohol, which are significantly inferior in effectiveness and also have an irritating effect (sting the skin, etc.). Boils, pimples, and minor inflammations on the skin also respond well to treatment with Baneocin powder. After treating such purulent skin lesions, recovery occurs quickly, and there is no need to cut out the boil with a scalpel.

Infants who have not yet learned to sweat properly often develop diaper dermatitis, which can also be easily treated with Baneocin powder. In the treatment of diaper dermatitis, Baneocin powder is used as baby powder. Recovery and complete epithelization of scars occurs after 4–10 days of using the powder. It is also great for treating heat rash in children.

Baneocin for chickenpox

Chickenpox blisters can and should be sprinkled with Baneocin powder, as this will prevent infection of the sores and dry them quickly and well to form a crust. It is necessary to treat all chickenpox blisters with Baneocin twice a day until a crust forms on them. After the crust has formed, you no longer need to sprinkle the bubbles with Baneocin powder. After the formation of crusts, so that there are no scars left, especially in the place of deep blisters, it is necessary to lubricate the sores with Contratubes or Solcoseryl.

Baneocin powder for chickenpox is an excellent substitute for traditional brilliant green, the effectiveness of which is lower, and the cosmetic properties are not very good. The powder relieves itching at the site of the blister, which prevents children from scratching the sore. Baneocin can be used to sprinkle blisters on chickenpox for both children and adults.
More about chickenpox

Baneocin for burns

An excellent remedy for the treatment of 1st, 2nd and 3rd degree burns with varying areas of damage is Baneocin. 1st and 2nd degree burns are quite common in children. Their distinguishing feature is peeling skin, blisters, or just redness. Such burns can be treated at home. Baneocin is also suitable for emergency treatment of a burn wound immediately after the incident.

Treatment of a burn wound with Baneocin is painless, very well tolerated and not accompanied by unpleasant sensations. Therefore, Baneocin powder is an excellent drug for treating burns at home. Treatment of the wound surface should be carried out twice a day until complete epithelialization, which usually occurs after 7 to 10 days. Sometimes treating a burn with the drug can cause allergies, redness, itching and dry skin.

The use of Baneocin for the treatment of 2nd degree burns significantly reduces the deepening of the lesion, accelerates the healing process and restoration of normal skin. The effectiveness of the drug is due to a significant reduction in the risk of wound infection, and the creation of favorable conditions for healing and restoration of the skin.

Baneocin for acne - a method of treatment

Since Baneocin is an antibacterial drug, it can be used to treat pimples, acne and inflammatory rashes on the face, especially purulent ones. Dermatologists recommend applying Baneocin ointment once a day, before bed, directly on acne and rashes, if there are few of them. If there are a lot of pimples and blackheads on the skin, then the ointment is applied to the entire affected area. The ointment should be applied in a thin layer in the evening and left overnight. In the morning, you need to wash your face and refresh it with tonic. Baneocin ointment can be used daily to treat acne for one to two weeks, after which you need to take a break. Then, if necessary, the course of treatment can be repeated. However, in most cases, 2 to 3 treatments are sufficient to eliminate pimples and blackheads.

Even severely inflamed acne is significantly reduced in size under the influence of Baneocin, after which it heals. You can also use the ointment to prevent the formation of pustules at the site of squeezed pimples. To do this, in the evening, squeeze out all pimples, comedones and blackheads, apply Baneocin ointment to these places and go to bed without washing off the drug. In the morning, the skin is usually clean and smooth, there are no traces of squeezed pimples, no red spots or pustules. In the morning, you need to wash your face with warm water and wipe with tonic.

Contraindications

Side effects

If the drug is used in large doses, or the skin lesion is extensive, absorption of Baneocin into the bloodstream may occur. Getting a large dose of Baneocin into the bloodstream can lead to the development of systemic side effects, which include toxic effects on the kidneys and ears, as well as disruption of the transmission of nerve impulses to the muscles.

In addition, side effects of Baneocin include allergic reactions at the site of application of the drug - redness, dry skin, rash and itching. In rare cases, allergies may develop in the form of contact eczema. This type of allergic reaction in half of the cases is associated with cross-allergy with other antibiotics - aminoglycosides (for example, Kanamycin, Tobramycin, Amikacin, Gentamicin, etc.). Therapy for chronic otitis media or dermatoses can lead to a decrease in sensitivity to other drugs, causing low effectiveness of the treatment.

Analogs

Levomekol or Baneocin?

Both ointments contain antibiotics as active ingredients. However, Levomekol contains only the antibiotic chloramphenicol, and Baneocin contains neomycin and bacitracin. Therefore, Baneocin is more effective against infection than Levomekol. Levomekol has the additional property of promoting scarring and rapid healing, but the ointment has a rather strong irritating effect. Both drugs are time-tested and have excellent effectiveness.

Levomekol is available only in the form of an ointment, and Baneocin is also available as a powder. Therefore, for dusting wounds, scratches, bites and other skin lesions in children, Baneocin is undoubtedly more convenient and practical. But adults can also use Levomekol. However, experts consider the antibacterial effect of Baneocin to be better than Levomekol. Therefore, it makes sense to choose Baneocin. If financial capabilities do not allow, then it is better to purchase Levomekol - its cost is less.

Reviews

To date, reviews of Baneocin are overwhelmingly positive. Parents of small children especially like it, as it perfectly replaces iodine and brilliant green. Any wounds, scratches and cuts can be treated completely painlessly, the powder does not sting the skin. As a result, the child does not try to refuse the wound treatment procedure. The powder is very convenient to use, you can take it with you for a walk, on vacation, to the country house, to the forest, etc. In a word, the advantages of Baneocin are simply enormous, for which he has earned preferably positive reviews.

Parents note that the drug is relatively cheap and lasts for a long period of time. Almost no one has written about the side effects of the drug or the development of allergies to it, but this phenomenon can occur. Therefore, when using Baneocin for the first time, carefully monitor the body’s reaction to the medicine.

Reviews of the use of Baneocin for acne

Author: Pashkov M.K. Content Project Coordinator.

Wound healing powders are topical powders that have a powerful antiseptic and regenerating effect. They are applied directly to the damaged area of ​​skin after initial treatment of the wound.

Photo 1. Powder products have a number of advantages. Source: Flickr (zack aksoti).

Is it possible to put medicine on an open wound?

Powder antiseptics can be used when when the skin damage is superficial and does not require suturing. This can be defined like this:

  1. cut depth is less than 6 mm;
  2. the width of the wound is relatively small, its edges do not need to be moved with your fingers to connect the edges;
  3. bleeding stops within 5 minutes after injury.

Note! If the cut is deep enough and/or wide, and fatty tissue, muscle tissue or bone is visible under the skin, then you need to consult a surgeon. In this case, it is unacceptable to use powders before the doctor arrives.

Wound treatment products in powder form

There are many powder preparations for treating wounds. Popular remedies include drugs based on sulfanilamide, bacitracin, neomycin, gentamicin, bismuth salt and other antimicrobial components.

Baneocin

The drug is available in the form of ointment and powder for external use. One gram of white crystalline powder contains 250 IU bacitracin and 5000 IU neomycin. This two bactericidal antibiotics, inhibiting the growth and reproduction of gram-positive pathogenic microorganisms, including staphylococci and streptococci.

It is important! In rare cases, Baneocin can cause ototoxic and nephrotoxic reactions - hearing loss and impaired renal function. According to the instructions for use, the drug can be applied to the affected area of ​​no more than 1% of the body area (no more than the size of the palm).

Streptocide

Streptocide belongs to the group of sulfonamides - broad-spectrum antimicrobial agents. Available in the form of tablets, as well as powder in plastic bags (2 g).

Indications for use: wounds, scratches, thermal and chemical burns, wound infection, erysipelas and other infections of the skin and soft tissues

Gentaxan

The drug is based on the aminoglycoside antibiotic gentamicin, zinc sulfate and L-tryptophan.

This combination antimicrobial drug based on antibiotic broad spectrum of action, which is applied to the wound surface using a dropper.

It is important! Gentaxan reduces the likelihood of keloid scar formation at the wound site.

Xeroform

Bismuth tribromophenolate powder (7 g) – antiseptic drug with astringent and drying effect. The active substance has an inhibitory effect on pathogenic microorganisms, preventing wound infection. Xeroform binds to tissue proteins and forms albuminates, creating a uniform thin film on the surface of the wound. Thanks to it, pain and irritation at the site of skin damage are reduced.

Rules for the use of drugs

Powder preparations for disinfection and healing of wounds – This not first aid.

  1. Before using them, the wound must be treated with mild soap with a bactericidal component, disinfected with chlorhexidine or hydrogen peroxide, then dried with a sterile paper towel.
  2. Most powders are applied directly to the wound up to 2-5 times a day.
  3. If a bandage is applied to the wound, then before applying the powder, pre-treatment may be required - removal of pus, rinsing with an antiseptic liquid. It is recommended to apply Streptocide not to the wound itself, but to a napkin placed on the damaged area.

Advantages and Disadvantages of Powder Medicines

Powdered medications with an antiseptic component are used to prevent infection of wounds, cuts, bites, abrasions, as well as after postoperative sutures, bedsores, trophic ulcers, 1-2 degree burns, boils and other skin lesions.

Most powders are based on antibiotics and antibacterial components - aminoglycosides, sulfonamides and other drugs and their combinations.

The advantage of using powdered wound care products is simplicity and relative safety of use, and high efficiency against most known microorganisms.

When applying the powder to an open area, there are no unpleasant sensations (burning, tingling).

Photo 2. Powder preparations are convenient to apply to the wound without injuring it by pressing. Source: Flickr (Harsha K R)

Due to the combined action of several components, some powder products not only protect against primary or secondary infection, but also accelerate regeneration and prevent the formation of keloid scars.

The disadvantages of wound treatment powders include contraindications and side effects, as well as possible toxic effects if released into the bloodstream. Before using any drug, you must carefully study the instructions.

Contraindications and side effects

All types of powder products are contraindicated in case of individual intolerance to the active and auxiliary components in the composition of the drugs. The most common side effect is an allergic skin reaction, which manifests itself in redness, itching, edema.

Other contraindications to powdered wound treatments:

  1. kidney diseases;
  2. thyrotoxicosis;
  3. disturbances in the functioning of the hematopoietic organs;
  4. simultaneous use with systemic aminoglycoside antibiotics is unacceptable for some powder antiseptics, for example Baneocin.

During pregnancy and breastfeeding the use of powdered products for external use is applied only with doctor's permission.

It is important! It is known that most active components are able to penetrate the bloodstream and pass through the placental barrier into the fetal circulatory system.