Bilirubin Direct

- Bilirubin, also known as bound bilirubin or “direct” bilirubin, is a form of erythrocyte bilirubin that differs from general bilirubin in its lower solubility and, as a result, greater ability to form stronger complexes with blood albumin. "Direct" means direct to albumin.

- Bilirubin glucuronoid and bound bilirubin. What was this bilirub called then?

How did this even come about? Because at that time this was the name given to all bilirubins that were formed as a result of the breakdown of hemoglobin in the blood. Subsequently, due to its insolubility, bilirubin began to be called “bound” or direct bilirubin, by analogy with the close connection of this substance with protein molecules.

What is bilirubin?

Direct bilirubin (from ancient Greek βίλος - blood and Greek λύμας - bile) is a product of the breakdown of hemoglobin, formed during erythropoiesis, due to which only 50−80% of hemoglobin completely decomposes. The rest of the hemoglobin is broken down by both direct and indirect metabolism through porphyrins.