Brady's

Bradykinin: functions and role in the body

Bradykinin is a naturally occurring polypeptide consisting of nine amino acids. This bioactive connective element performs important functions in the body, including regulating blood pressure, increasing capillary permeability, and contracting smooth muscle. Bradykinin also plays an important role as a mediator of inflammation.

Functions of bradykinin

Blood Pressure Regulation

Bradykinin has a pronounced vasodilator effect. This polypeptide causes dilation of blood vessels and a decrease in vascular resistance, which leads to a decrease in blood pressure. Vasodilation also increases the flow of oxygen and nutrients to the body's tissues and organs.

Increased capillary permeability

Bradykinin increases capillary permeability, which allows proteins and other molecules to pass through the walls of blood vessels. It plays an important role in the immune system, allowing proteins such as antibodies and complement components to enter tissue and fight infection.

Smooth muscle contraction

Bradykinin causes contraction of smooth muscle, which is found in the walls of blood vessels, organs and other tissues. This can cause blood vessels to shrink and narrow, which increases blood pressure. However, in general, bradykinin has a vasodilatory effect.

Inflammatory mediator

Bradykinin is considered an important mediator of inflammation. It is involved in a process called the kinin system, which includes a number of biologically active compounds. When tissues are damaged, bradykinin is released and causes vascular changes that lead to increased capillary permeability and migration of leukocytes into the tissue, which helps fight infection and repair damaged tissue.

Conclusion

Bradykinin is an important biologically active connective element that has many functions in the body, including regulating blood pressure, increasing capillary permeability, and contracting smooth muscle. Bradykinin also plays an important role as a mediator of inflammation. Understanding the functions of bradykinin can help in the development of new drugs to treat various diseases associated with disturbances in its regulation and functioning in the body.

Bradykinin is a naturally occurring polypeptide consisting of nine amino acids. Bradykinin has a pronounced vasodilator effect, increases capillary permeability and causes contraction of smooth muscles; formed in the blood under certain conditions. It is believed to play an important role as a mediator of inflammation. Bradykinin belongs to a group of substances called kinins and is one of the main physiologically active peptides of this group.

The formation of bradykinin in the body occurs during the activation of the kallikrein-kinin system. When tissue is damaged, the enzyme kallikrein is released, which breaks down kininogen to form bradykinin.

The main physiological effects of bradykinin:

1. Dilatation of blood vessels, especially arterioles and precapillary sphincters. This leads to increased blood flow.

2. Increased capillary permeability, which promotes tissue swelling.

3. Stimulation of nociceptive nerve endings causing pain.

4. Contraction of smooth muscles of the bronchi, intestines, and uterus.

Thus, bradykinin plays a key role in the development of the inflammatory response, tissue swelling, pain and other symptoms of inflammation. Kallikrein inhibitors and bradykinin receptor antagonists are considered potential anti-inflammatory agents.

Bradykinin is a biologically active substance that serves as one of the important components of the regulation of vascular tone and inflammation processes in the human body. Bradykinins are natural breakdown products of the large polypeptide bradykininase-2. They can be used in several areas of human life, such as medicine and pharmacy.

Role in physiology The release of endogenous kinins is generally associated with inflammation, mainly the inflammatory response to tissue damage