Chamberlain Symptom

Chamberlain's symptom

Chamberlain's sign is a radiological symptom described by the American radiologist Edward Winslow Chamberlain (1892-1947).

This symptom appears as darkening of the pelvic bones on x-ray in patients with multiple myeloma. In this disease, the bone marrow is damaged by tumor plasma cells, which leads to disruption of the structure of bone tissue. X-rays show that the pelvic bones become less transparent than normal, and dark areas appear - the so-called “smoky veil”.

Thus, the Chamberlain symptom allows one to suspect myeloma during an X-ray examination of the pelvis. It was first described by Chamberlain in 1930 and named after him. This symptom has important diagnostic value for the timely detection of multiple myeloma.

Chamberlain's symptom, or clutch syndrome (from the English clutch - a sharp jerk with the arms with a swing) is a rare neurological disease that manifests itself in the form of a sharp bending of the fingers into configurations opposed to the fist. This symptom is a separate manifestation of polyarthritis or polymicromyalgia with polyneropathy (orphan disease), and is also very