Co-Trimoxazole-Icn

Co-Trimoxazole-ICN: description, application and side effects

Co-trimoxazole-ICN is a combination antimicrobial medicine used to treat a variety of infections caused by bacteria. It contains two active ingredients: sulfamethoxazole and trimethoprim. Co-trimoxazole-ICN is produced in Russia by the company ICN Leksredstva and is available in the form of tablets and suspension for oral administration.

Application

Co-trimoxazole-ICN is used to treat various infections caused by bacteria. It may be effective in the treatment of respiratory tract infections, urinary tract infections, urogenital infections, gastrointestinal infections, skin infections, ENT infections, surgical infections, septicemia, meningitis, osteomyelitis, brain abscess, acute brucellosis, South American blastomycosis, malaria ( Plasmodium falciparum), toxoplasmosis and whooping cough (as part of complex therapy).

Side effects

Co-trimoxazole-ICN may cause some side effects. From the gastrointestinal tract, dyspepsia, nausea, vomiting, anorexia may occur, rarely - cholestatic and necrotizing hepatitis, increased transaminases and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis. From the hematopoietic organs, agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia may occur. From the urinary system, crystalluria, renal failure, interstitial nephritis, increased plasma creatinine, toxic nephropathy with oliguria and anuria may occur. Allergic reactions may include urticaria, rash, toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, allergic myocarditis, erythema multiforme, exfoliative dermatitis, Quincke's edema, itching, scleral redness and fever. Other side effects may include hyperkalemia, hyponatremia, and aseptic meningitis.

Contraindications

Co-trimoxazole-ICN is contraindicated in case of allergy to sulfonamides or trimethoprim, severe renal or liver failure, glucose-6-phosphate dehydrogenase deficiency, megaloblastic anemia, pregnancy and breastfeeding. It is not recommended for use in children under 6 weeks of age and in patients with asthma or an allergy to aspirin. Before using Co-trimoxazole-ICN, you should consult your doctor.