Collagenosis, Connective-Tissue Disease

Collagenosis, Connective-Tissue Disease: Inflammation that affects all body systems

Introduction:
Collagenosis, also known as diffuse connective tissue disease, is a group of diseases characterized by inflammatory changes in connective tissue. These changes can occur in various body systems and have a wide range of clinical manifestations. Currently, collagenoses include diseases such as dermatomyositis, systemic and discoid lupus erythematosus, annular scleroderma, polyarthritis nodosa and rheumatoid arthritis. In this article we will take a closer look at these diseases and their general characteristics.

General characteristics of collagenosis:
Collagen diseases are a group of autoimmune diseases in which the body's immune system attacks its own tissues. In the case of collagenosis, the main target of attack is the connective tissue containing collagen, the main structural protein of the body. As a result of inflammation and damage to connective tissue, characteristic clinical symptoms occur.

Collagenosis can affect various body systems, including skin, muscles, joints, lungs, kidneys, heart and other organs. Each disease has its own unique clinical manifestations, but common symptoms for all collagen diseases are inflammation, pain, limitation of movement and general weakness.

Main types of collagenosis:

1. Dermatomyositis:

   1. Dermatomyositis is characterized by inflammation of the skin and skeletal muscles.
   2. It can manifest as skin rashes, muscle weakness and pain.
   3. In some cases, there may be complications associated with damage to internal organs such as the lungs or heart.

2. Systemic lupus erythematosus:

   1. Systemic lupus erythematosus, also known as systemic lupus erythematosus (SLE), is a chronic inflammatory disease that can affect the skin, joints, kidneys, heart and other organs.
   2. The main symptoms are skin rashes, joint pain, fatigue and increased sensitivity to sunlight.
   3. In some cases, SLE can lead to serious complications such as kidney or lung damage.

3. Discoid lupus erythematosus:

   1. Discoid lupus erythematosus, or discoid lupus erythematosis, is characterized by inflammation of the skin, especially on the face, neck and scalp.
   2. It appears as red, scaly rashes that may be sensitive to sunlight.
   3. Unlike systemic lupus erythematosus, the discoid form does not usually affect internal organs.

4. Ring-shaped scleroderma:

   1. Ring-shaped scleroderma is characterized by thickening and tightness of the skin, especially on the hands and face.
   2. It can lead to limited movement and redness of the fingers and toes when exposed to cold or stress.
   3. In some cases, there may be damage to internal organs such as the lungs, heart or kidneys.

5. Polyarthritis nodosa:

   1. Polyarthritis nodosa is characterized by inflammation of multiple joints.
   2. It can cause pain, inflammation, limited movement, and joint deformity.
   3. Joint damage can be symmetrical and lead to impairment of overall mobility.

6. Rheumatoid arthritis:

   1. Rheumatoid arthritis is also a chronic inflammatory joint disease.
   2. It is characterized by inflammation, pain and deformity of the joints, especially in the arms and legs.
   3. Rheumatoid arthritis can also affect internal organs such as the lungs and heart.

Conclusion:
Collagenosis, a diffuse connective tissue disease, is a group of diseases that are characterized by inflammation of connective tissue and can affect various body systems. Dermatomyositis, systemic and discoid lupus erythematosus, annular scleroderma, polyarthritis nodosa and rheumatoid arthritis are examples of collagenoses. Early diagnosis and timely treatment play an important role in managing these diseases and reducing their negative impact on patients. Further research and development of new treatment methods will help improve the prognosis and quality of life of patients suffering from collagen diseases.

Connective tissue collagenosis is a pathological process accompanied by damage to the connective tissue of various organs and systems with the development of immune inflammation, which is accompanied by: tissue fibrosis; proliferation of pathological cellular elements; blood clotting. Connective tissue diseases often manifest as degenerative processes in muscle tissue.

Collagen diseases include: systemic scleroderma; lupus erythematosus; rheumopolyarthropatitis; scleredomia; dermatomyositis; diffuse pneumosclerosis.

Collagen syndrome involves the involvement of various parts of the musculoskeletal system: the skeletal system is deformed, cartilage loses its elasticity, transverse striations form on the fingers and toes; in to

Collagenoses are syndromes that develop with various connective tissue pathologies. These types of diseases are based on the inflammatory process, which includes sclerosis and atrophy in tissues other than the skin and its appendages. Pathology of connective tissue can be associated with many factors, including genetic predisposition, exposure to other diseases, bad habits, environment (including vibration), infection, etc. There is an assumption that the cause of many collagenoses may be an overdose of toxins or enzymes. Treatment of patients with connective tissue diseases is a complex process. Immunosuppressive drugs are used, and sometimes cytotoxic drugs are prescribed. Stem cell transplantation is sometimes used.