Colorado Tick Fever, also known as Tickborne Rift Valley Fever or CVTF, is a severe viral disease caused by an arbovirus and transmitted through a tick bite. The disease is characterized by high fever, fatigue, headache, muscle pain and skin rashes. The tick is the most common carrier of the disease and spreads throughout the countries of the Middle East, Europe, South Asia and North Africa. A febrile infection occurs in an acute period, which usually lasts from five to seven days and begins about a week after the tick bite. The intensity of the intoxication form of the disease is very diverse and manifests itself as mild benign fever and severe encephalitis, even with a fatal outcome. The main source of the disease is sick animals, especially cattle. The wearer can remain healthy for a certain period of time. However, usually only 2% of transmission carriers of the pathogen are sick; according to other sources, up to 50% of carriers can be infected and transmit the infection. The number of infected ticks and animals surrounding an infected food resource directly influences the severity of infection in humans. Cloadozoosphere pathogens and their related pathogens are known to be rare in populations in the United States, despite the wide distribution of the virus in countries such as Japan, the United States, and other countries where mites are used as biochemical elements for measuring humidity, which is why they talk about the “Control Response Hypothesis.” Studies conducted by epidemiologists in recent decades show that most cases of CVTF occur in endemic areas or after visiting one infected area and/or visiting livestock from it. In addition, the disease was identified through the development of a vaccine. The necessary vaccines were developed as clinicians everywhere sought to investigate and prevent CVTF, as well as its diagnostic tests for rapid and accurate diagnosis, especially in this demographic sector. The CVTF vaccine is a preventive treatment approved worldwide.