Coombs Antiglobulin Serum

Coombs antiglobulin serum is a diagnostic reagent used to detect an indirect antiglobulin test (Coombs) reaction. It contains antibodies to immunoglobulins and human complement.

This reagent was developed in 1945 by the English immunologist Robin Coombs and is used to detect incomplete antibodies fixed on red blood cells. It allows you to detect sensitization of erythrocytes by antibodies that themselves do not cause agglutination.

Coombs serum is widely used in clinical laboratory diagnostics when examining patients with suspected hemolytic disease of the newborn, autoimmune hemolytic anemia, for selecting compatible blood and for other purposes. It allows you to detect the presence of incomplete antibodies on the surface of red blood cells.

Thus, Coombs antiglobulin serum is an important diagnostic tool developed by Robin Coombs that is widely used in laboratory medicine. It allows detection of sensitization of red blood cells by incomplete antibodies.