Coombs Test

Coombs Test

The Coombs Test is a method for determining Rh antibodies on the surface of red blood cells, which cause the precipitation of globulins in the blood serum. This test is used to diagnose hemolytic anemia in infants with Rh incompatibility who have red blood cell destruction.

The Coombs reaction is based on the detection of antibodies that have bound to antigens on the surface of red blood cells. To do this, antiglobulin serum containing antibodies to human immunoglobulins is added to the red blood cells. If antibodies are present on the surface of red blood cells, agglutination occurs. This indicates the presence of alloimmune antibodies that cause hemolytic disease of the newborn.

The Coombs test is widely used in obstetric practice to detect Rh conflict between mother and fetus. It allows timely treatment and prevention of the development of severe hemolytic anemia in a newborn.

The Coombs test is a method for detecting Rh antibodies, which can cause globulin precipitation in the blood serum, which can lead to hemolytic disease of the newborn. This method is used to diagnose Rh conflict in pregnant women who have Rh antibodies.

The Coombs test uses red blood cells treated with antiglobulin antibodies. If a person has Rh antibodies, they can bind to red blood cells and cause their destruction. As a result of this process, hemolyzed red blood cells are formed, which become visible under a microscope.

This method is used to diagnose various diseases associated with the destruction of red blood cells, such as hemolytic anemia, sickle cell anemia and others. It can also be used to diagnose infections such as malaria and leishmaniasis, which can also cause red blood cell destruction.

The Coombe test is a test used to detect antibodies present in the blood that react with red blood cells. This test is an important test in the diagnosis of certain blood diseases such as hemolytic anemia. This is a sensitive and specific analysis that helps make an accurate diagnosis and prescribe the necessary treatment. The Coombe reaction is carried out in a complex manner. First, whole blood is tested for plasma and granules are prescribed. After which the sample is repeated, but the granules are mixed with a blood antigen - a special solution. The resulting slurry flows into a dense solid form, which causes the fixed form to become colored. The exact result is determined by the color of the resulting solution.