Darling's cytomycosis

Darling's cytomycosis is a rare fungal disease caused by the yeast-like fungus Histoplasma capsulatum. This fungus is widespread in nature and is most often found in soil enriched with bird and bat droppings.

The disease was named after the American pathologist Samuel Darling, who first described it in 1906.

The causative agent of Darling's cytomycosis enters the human body through airborne droplets. When fungal spores are inhaled, they settle in the lungs and cause an inflammatory process that can spread to other organs.

Characteristic symptoms include cough, fever, night sweats, and weight loss. Ulcers and painful nodules may be seen in the lungs, liver, spleen, and bone marrow.

Diagnosis is based on detection of the pathogen in sputum, blood or tissue. Treatment is carried out with antimycotic drugs, mainly azole derivatives. With timely treatment, the prognosis is favorable.

Several variants of the course of Darling's cytomycosis have been described, from acute to chronic. The disease is dangerous due to the development of severe complications, and therefore requires careful medical supervision. Prevention includes avoiding contact with contaminated soil.