Depakine Chrono 500
Country of origin: France
Pharm-Group: Anticonvulsants - valproates
Manufacturers: Sanofi Winthrop Industry (France)
International name: Valproic acid
Synonyms: Apilepsin, Acediprol, Valparin HR, Depakin, Depakin 300 enteric, Depakin chrono, Depakin-chrono, Dipromal, Konvulex, Convulsofin, Orfiril, Everiden, Encorat
Dosage forms: film-coated tablets
Composition: Active ingredient - Valproic acid.
Indications for use: Various forms of generalized seizures: small (absences), large (convulsive) and polymorphic; used for focal seizures, childhood tics.
Contraindications: Hypersensitivity, incl. “familial” (death of close relatives while taking valproic acid), diseases of the liver and pancreas (in some patients there may be a significant decrease in metabolism in the liver), hemorrhagic diathesis, pregnancy (first trimester), breastfeeding. Restrictions on use. Children's age (simultaneous administration of several anticonvulsants), bone marrow aplasia, pregnancy (late stages).
Side effects: Nausea, vomiting, diarrhea, stomach pain, anorexia or increased appetite, impaired liver function, drowsiness, tremor, paresthesia, confusion, peripheral edema, bleeding, leukopenia, thrombocytopenia. With long-term use - temporary hair loss.
Interaction: The effect is enhanced by other anticonvulsants, sedatives and hypnotics. Dyspeptic disorders develop less frequently against the background of antispasmodics and enveloping agents. Alcohol and other hepatotoxic drugs increase the likelihood of liver damage, anticoagulants or acetylsalicylic acid - the risk of bleeding.
Overdose: No data available.
Special instructions: No data available.
Literature: Encyclopedia of Medicines 2004