Depolarization Block

Depolarization is the process by which the electrical potential of the cell membrane becomes more positive compared to the internal environment. In neurophysiology, depolarization can be caused by various factors, such as an increase in the concentration of sodium or calcium ions in the cytoplasm.

Depolarizing blockers are medications that cause depolarization at the end plate at the neuromuscular junction. They are used to relax muscles in various diseases such as myasthenia gravis, myotonic dystrophy and other neuromuscular diseases.

One of the most well-known depolarizing blockers is suxamethonium (listenone). It blocks the transmission of excitation at the end plate, which leads to muscle relaxation. The listhenon block is called a depolarizing block because it causes long-term depolarization of the endplate membrane, which impairs neuromuscular conduction.

In clinical practice, the depolarizing block is used for general anesthesia, as well as for the treatment of neuromuscular diseases. It is also used as an adjuvant to relieve pain during surgical procedures. However, depolarizing block may cause side effects such as respiratory muscle paralysis, apnea, bradycardia and decreased blood pressure. Therefore, before using a depolarizing block, it is necessary to conduct a thorough examination of the patient and evaluate the risks and benefits of its use.

Depolarization block is a disorder of neuromuscular conduction that occurs during the action of muscle relaxants. Muscle relaxants cause prolonged depolarization of the end plate, which leads to disruption of the transmission of nerve impulses.

Depolarization block may manifest as muscle weakness or paralysis. It can be caused by various drugs such as curare, pancuronium, succinylcholine and others.

To treat depolarization block, it is necessary to stop the action of the muscle relaxant and restore neuromuscular conduction. This can be achieved by administering anticholinesterase drugs such as proserine or by applying electrical stimulation.

However, depolarization block can also be caused by other causes, such as injury, infection, or disease of the nervous system. In this case, treatment should be aimed at eliminating the underlying cause.